Show simple item record

dc.contributor.authorBidinotto, Lucas T. [UNESP]
dc.contributor.authorCosta, Celso A. R. A. [UNESP]
dc.contributor.authorCosta, Mirtes [UNESP]
dc.contributor.authorRodrigues, Maria Aparecida Marchesan [UNESP]
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.date.accessioned2014-05-20T13:37:18Z
dc.date.available2014-05-20T13:37:18Z
dc.date.issued2012-02-01
dc.identifierhttp://dx.doi.org/10.1089/jmf.2010.0278
dc.identifier.citationJournal of Medicinal Food. New Rochelle: Mary Ann Liebert Inc., v. 15, n. 2, p. 161-168, 2012.
dc.identifier.issn1096-620X
dc.identifier.urihttp://hdl.handle.net/11449/12888
dc.description.abstractLemongrass (Cymbopogon citratus Stapf) essential oil has been used worldwide because of its ethnobotanical and medicinal usefulness. Regarding its medicinal usefulness, the present study evaluated the beneficial effects of lemongrass essential oil (LGEO) oral treatment on cell proliferation and apoptosis events and on early development of hyperplastic lesions in the mammary gland, colon, and urinary bladder induced by N-methyl-N-nitrosourea (MNU) in female BALB/c mice. The animals were allocated into three groups: G1, treated with LGEO vehicle for 5 weeks (five times per week); G2, treated with LGEO vehicle as for GI and MNU (two injections each of 30 mg/kg of body weight at weeks 3 and 5); and G3, treated with LGEO (five times each with 500 mg/kg of body weight per week) and MNU as for G2. Twenty-four hours after the last MNU application, all animals were euthanized, and mammary glands, colon, and urinary bladder were collected for histological and immunohistochemical analysis. LGEO oral treatment significantly changed the indexes of apoptosis and/or cellular proliferation for the tissues analyzed. In particular, the treatment reduced the incidence of hyperplastic lesions and increased apoptosis in mammary epithelial cells. This increment in the apoptosis response may be related to a favorable balance in Bel2/Bax immunoreactivity in mammary epithelial cells. These findings indicate that LGEO presented a protective role against early MNU-induced mammary gland alterations in BALB/c mice.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent161-168
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc.
dc.relation.ispartofJournal of Medicinal Food
dc.sourceWeb of Science
dc.subjectapoptosisen
dc.subjectcell proliferationen
dc.subjectfemale BALB/c miceen
dc.subjectlemongrass essential oilen
dc.subjectN-methyl-N-nitrosoureaen
dc.titleModifying Effects of Lemongrass Essential Oil on Specific Tissue Response to the Carcinogen N-Methyl-N-Nitrosurea in Female BALB/c Miceen
dc.typeArtigo
dcterms.licensehttp://www.liebertpub.com/reprints/journal-of-medicinal-food/38/
dcterms.rightsHolderMary Ann Liebert Inc.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationSão Paulo State Univ, Dept Morphol, Inst Biosci, BR-18618900 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Pharmacol, Inst Biosci, BR-18618900 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Fac Med, Dept Pathol, BR-18618900 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Morphol, Inst Biosci, BR-18618900 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Pharmacol, Inst Biosci, BR-18618900 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Fac Med, Dept Pathol, BR-18618900 Botucatu, SP, Brazil
dc.identifier.doi10.1089/jmf.2010.0278
dc.identifier.wosWOS:000299852500008
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 06/58174-0
dc.description.sponsorshipIdFAPESP: 06/07195-8
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.fileWOS000299852500008.pdf
dc.identifier.lattes3278528112652257
unesp.author.lattes3278528112652257
unesp.author.orcid0000-0002-6909-8347[1]
dc.relation.ispartofjcr1.954
Localize o texto completo

Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record