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dc.contributor.authorSimielli Fonseca, Larissa Fernanda [UNESP]
dc.contributor.authorJovino Gimenez, Daniele Fernanda [UNESP]
dc.contributor.authorZerlotti Mercadante, Maria Eugenia
dc.contributor.authorMartins Bonilha, Sarah Figueiredo
dc.contributor.authorFerro, Jesus Aparecido [UNESP]
dc.contributor.authorBaldi, Fernando [UNESP]
dc.contributor.authorPablos de Souza, Fabio Ricardo
dc.contributor.authorAlbuquerque, Lucia Galvao de [UNESP]
dc.date.accessioned2015-10-21T20:39:40Z
dc.date.available2015-10-21T20:39:40Z
dc.date.issued2015-02-01
dc.identifierhttp://link.springer.com/article/10.1007%2Fs11033-014-3801-6
dc.identifier.citationMolecular Biology Reports, v. 42, n. 2, p. 559-565, 2015.
dc.identifier.issn0301-4851
dc.identifier.urihttp://hdl.handle.net/11449/129237
dc.description.abstractSeveral measures have been proposed to investigate and improve feed efficiency in cattle. One of the most commonly used measure of feed efficiency is residual feed intake (RFI), which is estimated as the difference between actual feed intake and expected feed intake based on the animal's average live weight. This measure permits to identify and select the most efficient animals without selecting for higher mature weight. Mitochondrial function has been indicated as a major factor that influences RFI. The analysis of genes involved in mitochondrial function is therefore an alternative to identify molecular markers associated with higher feed efficiency. This study analyzed the expression of PGC1 alpha, TFAM, UCP2 and UCP3 genes by quantitative real-time PCR in liver and muscle tissues of two groups of Nellore cattle divergently ranked on RFI values in order to evaluate the relationship of these genes with RFI. In liver tissue, higher expression of TFAM and UCP2 genes was observed in the negative RFI group. Expression of PGC1 alpha gene did not differ significantly between the two groups, whereas UCP3 gene was not expressed in liver tissue. In muscle tissue, higher expression of TFAM gene was observed in the positive RFI group. Expression of PGC1 alpha, UCP2 and UCP3 genes did not differ significantly between the two groups. These results suggest the use of TFAM and UCP2 as possible candidate gene markers in breeding programs designed to increase the feed efficiency of Nellore cattle.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent559-565
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.sourceWeb of Science
dc.subjectQuantitative real-time PCRen
dc.subjectLiver tissueen
dc.subjectMuscle tissueen
dc.subjectPGC1 alphaen
dc.subjectTFAMen
dc.subjectUCP2en
dc.subjectUCP3en
dc.titleExpression of genes related to mitochondrial function in Nellore cattle divergently ranked on residual feed intakeen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCtr Pesquisa Pecuaria Corte
dc.contributor.institutionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.contributor.institutionUniversidade Federal de Pelotas (UFPel)
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Zootecnia, Fac Ciencias Agr &Vet, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationCtr Pesquisa Pecuaria Corte, Inst Zootecnia, BR-14160000 Sertaozinho, SP, Brazil
dc.description.affiliationConselho Nacl Desenvolvimento Cient &Tecnol CNPq, BR-71605001 Lago Sul, DF, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Tecnol, Fac Ciencias Agr &Vet, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUniv Fed Pelotas, Dept Zool &Genet, BR-96010900 Pelotas, RS, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Zootecnia, Fac Ciencias Agr &Vet, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Tecnol, Fac Ciencias Agr &Vet, BR-14884900 Jaboticabal, SP, Brazil
dc.identifier.doi10.1007/s11033-014-3801-6
dc.identifier.wosWOS:000349006900027
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 2009/16118-5
dc.description.sponsorshipIdFAPESP: 2010/13502-6
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
dc.identifier.lattes0147241723612464
unesp.author.lattes0147241723612464
unesp.author.orcid0000-0002-2030-7590[8]
dc.relation.ispartofjcr1.889
dc.relation.ispartofsjr0,721
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