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dc.contributor.authorMartins, Luciamáre Perinetti Alves
dc.contributor.authorCastanho, Roberto Esteves Pires
dc.contributor.authorTherezo, Altino Luiz Silva
dc.contributor.authorRibeiro, Aline Rimoldi
dc.contributor.authorLima, Luciana
dc.contributor.authorTeixeira, Marta Maria Geraldes
dc.contributor.authorSperanca, Marcia Aparecida
dc.contributor.authorRodrigues, Vera Lucia Corrêa
dc.contributor.authorRosa, João Aristeu da [UNESP]
dc.date.accessioned2015-10-21T20:57:42Z
dc.date.available2015-10-21T20:57:42Z
dc.date.issued2015-03-01
dc.identifierhttp://www.degruyter.com/view/j/ap.2015.60.issue-1/ap-2015-0009/ap-2015-0009.xml
dc.identifier.citationActa Parasitologica. Berlin: Walter De Gruyter Gmbh, v. 60, n. 1, p. 65-74, 2015.
dc.identifier.issn1230-2821
dc.identifier.urihttp://hdl.handle.net/11449/129376
dc.description.abstractAn isolate of Trypanosoma cruzi obtained from P. megistus captured in the peridomicile area of a home in Santo Antonio do Jardim city in the State of Sao Paulo, denominated T. cruzi Mogi, was characterized biologically and molecularly. The RFLP analysis of the D7 divergent domain in the 24S alpha rDNA and of the mini-exon positioned the T. cruzi isolate within the TcI group. Phylogenetic analysis performed with the trypanosomatid barcode confirmed that the isolate belongs to the TcI group, with high homology to the 3014 c1 T. cruzi strain. The biological characterization of the isolate in rats showed a prepatent period of about 8 days, low parasitemia and tropism for cardiac, skeletal and colonic muscles. In Swiss mice the T. cruzi Mogi isolate showed a prepatent period of about 22 days, intermittent parasitemia in some animals, and tropism for cardiac and colonic muscles. Despite the inherent difficulty of identifying correlations amongst the molecular and biological characteristics of different T. cruzi groups, the tropism for colonic muscle demonstrated by T. cruzi Mogi represented a peculiarity of this isolate within the TcI group.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent65-74
dc.language.isoeng
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofActa Parasitologica
dc.sourceWeb of Science
dc.subjectTrypanosoma cruzien
dc.subjectChagas'diseaseen
dc.subjectCharacterizationen
dc.subjectLineageen
dc.subjectDNAen
dc.subjectStrainsen
dc.titleBiological and molecular characterization of a Trypanosoma cruzi isolate obtained from Panstrongylus megistus captured in Sao Paulo State, Brazilen
dc.typeArtigo
dcterms.licensehttp://www.degruyter.com/dg/page/20/rechte-lizenzen
dcterms.rightsHolderWalter De Gruyter Gmbh
dc.contributor.institutionFaculdade de Medicina de Marília (FAMEMA)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionSuperintendência de Controle de Endemias de Mogi-Guaçu
dc.description.affiliationUniversidade Estadual de Campinas, Departamento de Biologia Animal, Instituto de Biologia
dc.description.affiliationUniversidade de São Paulo, Instituto de Ciências Biomédicas
dc.description.affiliationUniversidade Federal do ABC, Centro de Ciências Naturais e Humanas
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas de Araraquara
dc.identifier.doi10.1515/ap-2015-0009
dc.identifier.wosWOS:000350421800009
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 2009/15824-3
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.lattes2635738091759784
unesp.author.lattes2635738091759784
dc.relation.ispartofjcr1.039
dc.relation.ispartofsjr0,641
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