Hydroxyapatite and a new fibrin sealant derived from snake venom as scaffold to treatment of cranial defects in rats
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Data
2015-01-01
Autores
Cunha, Marcelo Rodrigues da
Menezes, Fernanda Araujo
Santos, Geovane Ribeiro dos
Lopes Pinto, Clovis Antonio
Barraviera, Benedito [UNESP]
Amaro Martins, Virginia da Conceicao
Guzzi Plepis, Ana Maria de
Ferreira Junior, Rui Seabra [UNESP]
Título da Revista
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Editor
Univ Fed Sao Carlos, Dept Engenharia Materials
Resumo
Biomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of bone and fibrin sealants due to their hemostatic properties. The objective was to evaluate the repair of cranial defects in 40 rats, grafted with hydroxyapatite and a new fibrin sealant derived from snake venom. The animals were divided into four groups: C (control, no graft); Ha (hydroxyapatite); FS (fibrin sealant), and HaFS (hydroxyapatite and fibrin sealant). The animals were euthanized 2 and 6 weeks after surgery and wound area were submitted to analysis. After 2 weeks, immature bone was formed from the borders of the defect and in groups Ha and HaFS, few hydroxyapatite particles were surrounded by new bone. After 6 weeks, the new bone was mature and surrounded several hydroxyapatite particles, without connective tissue interposition and the volume of new bone was higher in HaFS group. The hydroxyapatite in combination with the new fibrin sealant accelerates bone repair.
Descrição
Palavras-chave
Bioceramic, Fibrin sealant, Bone regeneration
Como citar
Materials Research-ibero-american Journal Of Materials, v. 18, n. 1, p. 196-203, 2015.