Ribifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activity
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Data
2015-03-01
Autores
Pinto, Meri Emili F. [UNESP]
Batista, Joao M. [UNESP]
Koehbach, Johannes
Gaur, Pratibha
Sharma, Abhinay
Nakabashi, Myna
Cilli, Eduardo Maffud [UNESP]
Giesel, Guilherme M.
Verli, Hugo
Gruber, Christian W.
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Amer Chemical Soc
Resumo
A new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 mu M) against the Plasmodium falciparum strain 3D7.
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Journal Of Natural Products. Washington: Amer Chemical Soc, v. 78, n. 3, p. 374-380, 2015.