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dc.contributor.authorAlmeida Prado, Patricia S. de
dc.contributor.authorSoares, Maria Fernanda
dc.contributor.authorLima, Flávio de Oliveira [UNESP]
dc.contributor.authorSchor, Nestor
dc.contributor.authorTeixeira, Vicente P. C.
dc.date.accessioned2014-05-20T13:37:36Z
dc.date.available2014-05-20T13:37:36Z
dc.date.issued2012-06-01
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2613.2012.00813.x
dc.identifier.citationInternational Journal of Experimental Pathology. Malden: Wiley-blackwell, v. 93, n. 3, p. 218-224, 2012.
dc.identifier.issn0959-9673
dc.identifier.urihttp://hdl.handle.net/11449/13034
dc.description.abstractInfravesical obstruction (IVO) secondary to benign prostatic hypertrophy can affect up to 50% of men over 50 years old and may cause serious and irreversible alterations throughout the urinary tract, especially in the bladder. Therapeutic approaches are currently limited. Amitriptyline has recently been described as an analgesic, anti-inflammatory and myorelaxant in some experimental models. The objective of this study was to investigate the effects of amitriptyline hydrochloride on the process of fibrosis in a bladder outlet obstruction model in rats. Male Wistar rats were subjected to IVO and studied at intervals of 1 and 14 days postprocedure. The rats were randomly divided into five groups: sham, IVO1-T, IVO1-NT, IVO14-T and IVO14-NT. Bladder tissue was processed for histopathology, immunohistochemistry and RT-PCR. The IVO14 groups presented bladder fibrosis, smooth muscle cell hypertrophy and bladder wall thickening. The IVO14-T group demonstrated a higher intensity of fibrosis, higher macrophage infiltration rate and higher gene expression of Transforming growth factor (TGF) Tgf-beta 1. Thus this data shows that in this experimental mode amitriptyline had an amplifying effect on the process of fibrosis as a whole.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent218-224
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofInternational Journal of Experimental Pathology
dc.sourceWeb of Science
dc.subjectamitriptylineen
dc.subjectbladder outlet obstructionen
dc.subjectfibrosisen
dc.subjectosteopontinen
dc.subjecttransforming growth factor-beta1en
dc.titleAmitriptyline aggravates the fibrosis process in a rat model of infravesical obstructionen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Fed São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal da Bahia (UFBA), Dept Morphol, Div Anat, Salvador, BA, Brazil
dc.description.affiliationUniv Fed São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliationState Univ São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnespState Univ São Paulo, Dept Pathol, São Paulo, Brazil
dc.identifier.doi10.1111/j.1365-2613.2012.00813.x
dc.identifier.wosWOS:000303989200008
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes2443296326760741
unesp.author.lattes2443296326760741
unesp.author.orcid0000-0001-8848-3040[3]
dc.relation.ispartofjcr1.938
dc.relation.ispartofsjr0,712
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