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dc.contributor.authorResende, Marco A. C. de [UNESP]
dc.contributor.authorPantoja, Alberto V.
dc.contributor.authorBarcellos, Bruno M.
dc.contributor.authorReis, Eduardo P. [UNESP]
dc.contributor.authorConsolo, Thays D. [UNESP]
dc.contributor.authorMódolo, Renata P. [UNESP]
dc.contributor.authorDomingues, Maria A. C. [UNESP]
dc.contributor.authorAssad, Alexandra R.
dc.contributor.authorCavalcanti, Ismar L.
dc.contributor.authorCastiglia, Yara M. M. [UNESP]
dc.contributor.authorMódolo, Norma S. P. [UNESP]
dc.date.accessioned2015-12-07T15:31:45Z
dc.date.available2015-12-07T15:31:45Z
dc.date.issued2015
dc.identifierhttp://dx.doi.org/10.1155/2015/864902
dc.identifier.citationBiomed Research International, v. 2015, p. 1-9, 2015.
dc.identifier.issn2314-6141
dc.identifier.urihttp://hdl.handle.net/11449/131118
dc.description.abstractBackground. Ischemic postconditioning (IP) in renal Ischemia reperfusion injury (IRI) models improves renal function after IRI. Ketamine affords significant benefits against IRI-induced acute kidney injury (AKI). The present study investigated the effects of IP and IP associated with subanesthetic S(+)-ketamine in ischemia-reperfusion-induced AKI. Methods. Forty-one Wistar rats were randomized into four groups: CG (10), control; KG (10), S(+)-ketamine infusion; IPG (10), IP; and KIPG (11), S(+)-ketamine infusion + IP. All rats underwent right nephrectomy. IRI and IP were induced only in IPG and KIPG by left kidney arterial occlusion for 30 min followed by reperfusion for 24 h. Complete reperfusion was preceded by three cycles of 2 min of reocclusion followed by 2 min of reperfusion. Renal function was assessed by measuring serum neutrophil gelatinase-associated lipocalin (NGAL), creatinine, and blood urea nitrogen (BUN). Tubular damage was evaluated by renal histology. Results. Creatinine and BUN were significantly increased. Severe tubular injury was only observed in the groups with IRI (IPG and KIPG), whereas no injury was observed in CG or KG. No significant differences were detected between IPG and KIPG. Conclusions. No synergic effect of the use of subanesthetic S(+)-ketamine and IP on AKI was observed in this rat model.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1-9
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofBioMed Research International
dc.sourcePubMed
dc.titleIschemic postconditioning and subanesthetic S(+)-Ketamine infusion: effects on renal function and histology in ratsen
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.description.affiliationPós-Graduação em Anestesiologia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, Brasil
dc.description.affiliationServiço de Anestesiologia, Departamento de Cirurgia, Universidade Federal Fluminense (UFF), 24033-900 Niterói, RJ, Brasil
dc.description.affiliationDepartamento de Patologia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, Brasil
dc.description.affiliationDepartamento de Anestesiologia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Patologia, Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Anestesiologia, Faculdade de Medicina de Botucatu
dc.identifier.doi10.1155/2015/864902
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2012/13606-1
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.filePMC4564631.pdf
dc.identifier.pubmed26413552
dc.identifier.pmcPMC4564631
dc.relation.ispartofsjr0,935
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