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dc.contributor.authorSato, J. O. [UNESP]
dc.contributor.authorCorrente, J. E. [UNESP]
dc.contributor.authorSaad-Magalhães, C. [UNESP]
dc.date.accessioned2015-12-07T15:31:49Z
dc.date.available2015-12-07T15:31:49Z
dc.date.issued2015
dc.identifierhttp://dx.doi.org/10.1177/0961203315599449
dc.identifier.citationLupus, v. 24, n. 13, p. 1421-1428, 2015.
dc.identifier.issn1477-0962
dc.identifier.urihttp://hdl.handle.net/11449/131125
dc.description.abstractThe objective of this article is to assess disease activity patterns and their relationship to damage, death and growth failure in a cohort of juvenile lupus. Chronic active, relapsing-remitting and long quiescent activity patterns were retrospectively classified according to longitudinal scores of both the Modified SLEDAI-2K and ECLAM. The Pediatric SLICC/ACR Damage Index (Ped-SDI) was scored at the last visit in patients followed more than six months. Survival analysis was performed considering death, damage and growth failure, and stratified according to disease activity patterns. Cox model analysis identified predictors for damage and growth failure among onset clinical variables. Thirty-seven patients with 11 years mean age at diagnosis and 3.2 years mean follow-up were studied. According to the Modified SLEDAI-2K, activity pattern was 67.5% relapsing-remitting, 29.8% chronic active and 2.7% long quiescent and by ECLAM, 45.9%, 48.7% and 5.4%, respectively. The five-year survival was 90%. Damage accrued in 62.5% and growth failure in 31.3%. Chronic active cases progressed to damage earlier than relapsing-remitting (log-rank test, p < 0.05). Damage was associated with disease duration (p < 0.0001), thrombocytopenia (p < 0.05) and alopecia (p < 0.004). Growth failure was associated with disease duration (p < 0.007) and renal failure (p < 0.007). Damage was observed in nearly two-thirds of patients, and occurred earlier in the chronic active pattern. Disease duration, thrombocytopenia and alopecia at onset predicted damage.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1421-1428
dc.language.isoeng
dc.publisherSAGE Publications
dc.relation.ispartofLupus
dc.sourcePubMed
dc.subjectChildhood-onset systemic lupus erythematosusen
dc.subjectDamageen
dc.subjectDisease activity patternsen
dc.subjectJuvenile systemic lupus erythematosusen
dc.subjectOutcomes researchen
dc.titleChronic active disease pattern predicts early damage in juvenile systemic lupus erythematosusen
dc.typeArtigo
dcterms.rightsHolderSAGE Publications
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationDepartamento de Pediatria, Faculdade de Medicina de Botucatu, UNESP – Universidade Estadual Paulista, São Paulo, Brasil
dc.description.affiliationDepartamento de Bioestatística, Instituto de Biociências, Campus de Botucatu, UNESP – Universidade Estadual Paulista, São Paulo, Brasil.
dc.description.affiliationUnespDepartamento de Pediatria, Faculdade de Medicina de Botucatu, UNESP – Universidade Estadual Paulista, São Paulo, Brasil
dc.description.affiliationUnespDepartamento de Bioestatística, Instituto de Biociências, Campus de Botucatu, UNESP – Universidade Estadual Paulista, São Paulo, Brasil.
dc.identifier.doi10.1177/0961203315599449
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 2014/07659-0
dc.description.sponsorshipIdCNPq: 301644-2010
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
dc.identifier.lattes7098310008371632
dc.identifier.pubmed26253073
dc.identifier.orcid0000-0001-5478-4996
dc.identifier.orcid0000-0002-7631-7093
unesp.author.lattes7098310008371632[3]
unesp.author.orcid0000-0001-5478-4996[2]
unesp.author.orcid0000-0002-7631-7093[3]
dc.relation.ispartofsjr1,410
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