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dc.contributor.authorAquino, Diana Figuereido de Santana
dc.contributor.authorPiccinelli, Ana Claudia
dc.contributor.authorSoares, Fabíola Lacerda Pires
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.authorSalvador, Marcos José
dc.contributor.authorKassuya, Candida Aparecida Leite
dc.date.accessioned2015-12-07T15:32:55Z
dc.date.available2015-12-07T15:32:55Z
dc.date.issued2015
dc.identifierhttp://dx.doi.org/10.1007/s10753-015-0187-0
dc.identifier.citationInflammation, v. 38, n. 6, p. 2057-2066, 2015.
dc.identifier.issn1573-2576
dc.identifier.urihttp://hdl.handle.net/11449/131237
dc.description.abstractAlternanthera maritima are used in Brazilian popular medicine for the treatment of inflammatory and infectious diseases. Species of Alternanthera have demonstrated biological activities in previous scientific studies. The aim of this study was to determine whether the ethanol extract of the aerial parts of A. maritima (EEAM) and the isolated compound 2″-O-α-L-rhamnopyranosyl-vitexin inhibit mechanical hyperalgesia and parameters of inflammation in mice. The oral administration of EEAM significantly inhibited carrageenan (Cg)-induced paw edema and reduced leukocyte migration into the pleural cavity. 2″-O-α-L-rhamnopyranosylvitexin significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. Both EEAM and 2″-O-α-L-rhamnopyranosylvitexin significantly prevented the Cg-induced hyperalgesia. Local administration of 2″-O-α-L-rhamnopyranosylvitexin significantly prevented the Cg- and tumor necrosis factor (TNF)-induced hyperalgesia. In conclusion, this study demonstrated that EEAM is an anti-inflammatory and anti-hyperalgesic agent, and the results suggested that 2″-O-α-L-rhamnopyranosylvitexin is responsible for the effects of EEAM and the mechanism involves the TNF pathway.en
dc.format.extent2057-2066
dc.language.isoeng
dc.publisherInflammation
dc.relation.ispartofInflammation
dc.sourcePubMed
dc.subjectAlternanthera maritimaen
dc.subjectAmaranthaceaeen
dc.subject2″-O-α-l-rhamnopyranosyl-vitexinen
dc.subjectInflammationen
dc.subjectHyperalgesiaen
dc.titleAnti-hyperalgesic and anti-inflammatory activity of Alternanthera maritima extract and 2″-O-α-L-rhamnopyranosylvitexin in miceen
dc.typeArtigo
dc.contributor.institutionCollege of Health Science, Federal University of Grande Dourados, Dourados, 79825-070, MS, Brazil.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionCollege of Health Science, Federal University of Grande Dourados, Dourados, 79825-070, MS, Brazil. candida2005@gmail.com.
dc.description.affiliationCollege of Health Science, Federal University of Grande Dourados, Dourados, 79825-070, MS, Brazil.
dc.description.affiliationDepartment of Morphology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, SP, Brazil.
dc.description.affiliationInstitute of Biology, Department of Plant Biology, PPG BTPB, and PPG BV, University of Campinas (UNICAMP), 13083-970, Campinas, São Paulo, Brazil.
dc.description.affiliationCollege of Health Science, Federal University of Grande Dourados, Dourados, 79825-070, MS, Brazil. candida2005@gmail.com.
dc.description.affiliationUnespDepartment of Morphology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, SP, Brazil.
dc.identifier.doi10.1007/s10753-015-0187-0
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
dc.identifier.lattes0729220781785349
dc.identifier.pubmed26045342
unesp.author.lattes0729220781785349
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