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dc.contributor.authorLopes, Danielle A.
dc.contributor.authorLemes, Jéssica A.
dc.contributor.authorMelo-Thomas, Liana
dc.contributor.authorSchor, Herbert
dc.contributor.authorde Andrade, José S.
dc.contributor.authorMachado, Carla M. [UNESP]
dc.contributor.authorHorta-Júnior, José de Anchieta de Castro e [UNESP]
dc.contributor.authorCéspedes, Isabel C.
dc.contributor.authorViana, Milena B.
dc.date.accessioned2015-12-07T15:39:27Z
dc.date.available2015-12-07T15:39:27Z
dc.date.issued2015-10-17
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2015.10.006
dc.identifier.citationBehavioural Brain Research, v. 297, p. 180-186, 2015.
dc.identifier.issn1872-7549
dc.identifier.urihttp://hdl.handle.net/11449/131648
dc.description.abstractIn previous studies, we verified that exposure to unpredictable chronic mild stress (UCMS) facilitates avoidance responses in the elevated T-maze (ETM) and increased Fos-immunoreactivity in different brain structures involved in the regulation of anxiety, including the dorsal raphe (DR). Since, it has been shown that the DR is composed of distinct subpopulations of serotonergic and non-serotonergic neurons, the present study investigated the pattern of activation of these different subnuclei of the region in response to this stress protocol. Male Wistar rats were either unstressed or exposed to the UCMS procedure for two weeks and, subsequently, analyzed for Fos-immunoreactivity (Fos-ir) in serotonergic cells of the DR. To verify if the anxiogenic effects observed in the ETM could be generalized to other anxiety models, a group of animals was also tested in the light/dark transition test after UCMS exposure. Results showed that the UCMS procedure decreased the number of transitions and increased the number of stretched attend postures in the model, an anxiogenic effect. UCMS exposure also increased Fos-ir and the number of double-labeled neurons in the mid-rostral subdivision of the dorsal part of the DR and in the mid-caudal region of the lateral wings. In the caudal region of the DR there was a significant increase in the number of Fos-ir. No significant effects were found in the other DR subnuclei. These results corroborate the idea that neurons of specific subnuclei of the DR regulate anxiety responses and are differently activated by chronic stress exposure.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científco e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent180-186
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofBehavioural Brain Research
dc.sourcePubMed
dc.subjectAnxietyen
dc.subjectDorsal rapheen
dc.subjectFos immunoreactivityen
dc.subjectSerotoninen
dc.subjectUnpredictable chronic mild stressen
dc.titleUnpredictable chronic mild stress exerts anxiogenic-like effects and activates neurons in the dorsal and caudal region and in the lateral wings of the dorsal raphe nucleusen
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionPhilipps-University of Marburg
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
dc.description.affiliationBehavioral Neuroscience, Experimental and Physiological Psychology, Philipps-University of Marburg, Marburg, Germany.
dc.description.affiliationDepartment of Anatomy, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.
dc.description.affiliationDepartment of Biosciences, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
dc.description.affiliationUnespDepartment of Anatomy, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.
dc.identifier.doi10.1016/j.bbr.2015.10.006
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 2013/17389-8
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
dc.identifier.pubmed26462572
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