Effect of vaccination and the immunomodulators bacillus of Calmette-Guerin, Avridine and Propionibacterium acnes on rabies in mice
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Data
1998-10-01
Autores
Megid, Jane [UNESP]
Peracolli, MTS
Curi, P. R.
Zanetti, C. R.
Cabrera, W. H.
Vassao, R.
Ito, F. H.
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Editor
Elsevier B.V.
Resumo
Responses: of vaccination and treatment to immunomodulators against rabies in mice were evaluated through macrophage inhibition factor (MIF), intra-pad inoculation (IPI) and serum neutralization (SN) tests and by the detection of gamma-interferon (IFN-gamma). Onco-BCG, Avridine and Propionibacterium acnes were administered to groups of mice. Higher survival rates were found in animals treated with P. acnes. Lower levels of IFN-gamma were observed in the groups of infected and vaccinated mice. The IPI was not effective on detecting the response of delayed-type hypersensitivity. Vaccine induced in the infected animals a more intense response to MIF reaction. (C) 1998 Elsevier B.V. Ltd. All rights reserved.
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Palavras-chave
rabies, immunomodulators, cellular immunity, humoral immunity, MIF, -INTERFERON, mice
Como citar
Comparative Immunology Microbiology and Infectious Diseases. Oxford: Pergamon-Elsevier B.V., v. 21, n. 4, p. 305-318, 1998.