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Now showing items 1-5 of 5
Budesonide-hydroxypropyl-beta-cyclodextrin inclusion complex in binary poloxamer 407/403 system for ulcerative colitis treatment: A physico-chemical study from micelles to hydrogels
(Colloids And Surfaces B-biointerfaces, 2016-02-01) [Artigo]
Budesonide (BUD) is a glucocorticoid widely used for the treatment of ulcerative colitis. In this work, we propose the study of the system BUD-HP-beta-CD inclusion complex incorporated into PL 407 and PL407-PL403 ...
Characterization of Articaine-Loaded Poly(epsilon-caprolactone) Nanocapsules and Solid Lipid Nanoparticles in Hydrogels for Topical Formulations
(Journal Of Nanoscience And Nanotechnology, 2018-06-01) [Artigo]
This work describes the development of poly-epsilon-caprolactone nanocapsules (PCL-NC) and solid lipid nanoparticles (SLN) aiming delivery for articaine (ATC), in order to improve its chemical stability in semi-solid ...
Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
(Química Nova, 2008-01-01) [Artigo]
Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the ...
Poloxamer-based binary hydrogels for delivering tramadol hydrochloride: sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation
(International Journal Of Nanomedicine, 2015-01-01) [Artigo]
In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release ...
Physico-Chemical Characterization and Biopharmaceutical Evaluation of Lipid-Poloxamer-Based Organogels for Curcumin Skin Delivery
(Frontiers In Pharmacology, 2019-09-12) [Artigo]
Organogels (ORGs) are semi-solid materials, in which an organic phase is immobilized by a three-dimensional network composed of self-organized system, forming the aqueous phase. In this context, lipid-Pluronics (PLs) ORGs ...