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Bupivacaine in alginate and chitosan nanoparticles: An in vivo evaluation of efficacy, pharmacokinetics, and local toxicity
(Journal of Pain Research, 2018-04-06) [Artigo]
Objective: This study reports a preclinical evaluation of an alginate/chitosan nanoparticle formulation containing NovaBupi®, a racemic bupivacaine (BVC) containing 25% dextrobupivacaine and 75% levobupivacaine. Methods: ...
Initial Development and Characterization of PLGA Nanospheres Containing Ropivacaine
(Journal of Biological Physics, 2007-12-01) [Artigo]
Local anesthetics are able to induce pain relief by binding to the sodium channels of excitable membranes, blocking the influx of sodium ions and the propagation of the nervous impulse. Ropivacaine (RVC) is an amino amide, ...