Now showing items 1-2 of 2
Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina
(Química Nova, 2008-01-01) [Artigo]
Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery ...
Interaction between nitroheterocyclic compounds with beta-cyclodextrins: Phase solubility and HPLC studies
(Journal of Pharmaceutical and Biomedical Analysis, 2008-08-05) [Artigo]
Chagas disease is a serious health problem for Latin America. Nitrofurazone (NF) and Hidroxymethylnitrofurazone (NFOH) are active against Trypanosoma cruzi. The effect of beta-cyclodextrin (beta-CD) and dimethyl-beta-cyclodextrin ...