Now showing items 1-4 of 4
Distribution of neutral prilocaine in a phospholipid bilayer: Insights from molecular dynamics simulations
(International Journal of Quantum Chemistry, 2008-11-05) [Artigo]
In this work, we report a 20-ns constant pressure molecular dynamics simulation of prilocaine (PLC), in amine-amide local anesthetic, in a hydrated liquid crystal bilayer of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine. ...
Encapsulation of Local Anesthetic Bupivacaine in Biodegradable Poly(DL-lactide-co-glycolide) Nanospheres: Factorial Design, Characterization and Cytotoxicity Studies
(Macromolecular Symposia, 2009-01-01) [Trabalho apresentado em evento]
Local anesthetic agents cause temporary blockade of nerve impulses productiong insensitivity to painful stimuli in the area supplied by that nerve. Bupivacaine (BVC) is an amide-type local anesthetic widely used in surgery ...
Benzocaine-loaded polymeric nanocapsules: Study of the anesthetic activities
(Journal of Pharmaceutical Sciences, 2012-03-01) [Artigo]
This paper describes a comparison of different polymeric nanocapsules (NCs) prepared with the polymers poly(d,l-lactide-co-glycolide), poly(l-lactide) (PLA), and poly(e-caprolactone) and used as carrier systems for the ...
Poly(Lactide-co-Glycolide) Nanocapsules Containing Benzocaine: Influence of the Composition of the Oily Nucleus on Physico-Chemical Properties and Anesthetic Activity
(Pharmaceutical Research, 2011-08-01) [Artigo]
The aim of this work was to investigate the influence of the oily nucleus composition on physico-chemical properties and anesthetic activity of poly (lactide-co-glycolide) nanocapsules with benzocaine.Nanocapsules containing ...