Now showing items 1-2 of 2
Distribution of neutral prilocaine in a phospholipid bilayer: Insights from molecular dynamics simulations
(International Journal of Quantum Chemistry, 2008-11-05) [Artigo]
In this work, we report a 20-ns constant pressure molecular dynamics simulation of prilocaine (PLC), in amine-amide local anesthetic, in a hydrated liquid crystal bilayer of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine. ...
Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
(Química Nova, 2008-01-01) [Artigo]
Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the ...