Estudos sobre o uso de NbCl5 como ácido de Lewis em reações de Povarov
Carregando...
Data
2011
Autores
Silva Filho, Luiz Carlos da [UNESP]
Frenhe, Mayara [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
The aim of this work was to investigate the use of NbCl5 as Lewis acid in cycloadittion reactions [Reaction Aza-Diels-Alder (Povarov)] between Schiff bases and enol ethers. Comparison of reaction yields, obtained products as well as reaction time with NbCl5 were also a key point on this work. In the aza-Diels-Alder reactions between Schiff bases and enol ethers (dihydropyran or dihydrofuran), the NbCl5 was an excellent catalyst for the synthesis of pyrano- and furanoquinoline derivatives. These derivatives are an important class of natural products that exhibit wide range of biological activity. The reactions were carried out at low concentration of niobium and in relatively short times, resulting in yields varying from 78 to 95%.
Descrição
Palavras-chave
Niobium pentachloride, Povarov reactions, Tetrahydroquinoline derivatives, Aza-Diels-Alder reactions
Como citar
Orbital: the Electronic Journal of Chemistry, v. 3, n. 1, p. 1-14, 2011.