Maternal treatment with fluoxetine promotes testicular alteration in male rat pups
Nenhuma Miniatura disponível
Data
2016
Autores
Ramos, Aline Camargo
Santos, Alice Hartmann dos
Silveira, Kennia Moura
Kiss, Ana Carolina Inhasz [UNESP]
Mesquita, Suzana de Fátima Paccola
Gerardin, Daniela Cristina Ceccatto
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRI) antidepressant commonly prescribed during pregnancy and lactation. Pre- and post-partum depression, as well as SSRI treatment during these periods, may change maternal care, interfering with offspring development. Moreover, it is known that SSRIs may alter testes structure and function in offspring. The present study investigated the effects of maternal FLX exposure on maternal behaviour and testes function in offspring. Female Wistar rats were treated with 7.5 mg kg 1 FLX or tap water (control group) by gavage from the Day 1 of pregnancy until 21 days after birth (postnatal Day (PND) 21). Maternal behaviour was evaluated and morphofunctional analyses of offspring testes were conducted on PND 21 and 50. There were no significant differences between the FLX-treated and control groups regarding maternal behaviour. Nor did maternal treatment with FLX have any effect on bodyweight gain, anogenital distance, day of preputial separation, testis weight and the gonadosomatic index in male offspring. However, there was a decreased number of Sertoli cells at both PND 21 and 50 in FLX-exposed male offspring. The findings of the present study demonstrate that maternal exposure to FLX can impair testicular function in weanling and pubertal animals.
Descrição
Palavras-chave
Antidepressant, Maternal behaviour, Tests
Como citar
Reproduction, Fertility and Development, v. 28, n. 8, p. 1206-1213, 2016.