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dc.contributor.authorMello, Marcia Sarpa de Campos
dc.contributor.authorDelgado, Isabella Fernandes
dc.contributor.authorFavareto, Ana Paula Alves [UNESP]
dc.contributor.authorLopes, Camila M. T.
dc.contributor.authorBatista, Marcelo Meuser
dc.contributor.authorKempinas, Wilma de Grava [UNESP]
dc.contributor.authorPaumgartten, Francisco José Roma
dc.date.accessioned2016-07-07T12:36:36Z
dc.date.available2016-07-07T12:36:36Z
dc.date.issued2015
dc.identifierhttp://dx.doi.org/10.1016/j.toxrep.2014.12.006
dc.identifier.citationToxicology Reports, v. 2, p. 405-414, 2015.
dc.identifier.issn2214-7500
dc.identifier.urihttp://hdl.handle.net/11449/141047
dc.description.abstractThis study investigated the effects of pre- and peripubertal exposure (PND 15–45) to triphenyltin hydroxide (TPT: 0, 1.875, 3.75, 7.5 and 15 mg/kg bw/d po) on mouse sexual maturation and fertility. Half of the mice were euthanized on PND 46 and the remaining mice were submitted to fertility tests on PND 65–75. TPT caused a transient decrease of weight gain at 3.75 mg/kg bw/d, and deaths and body weight deficits at higher doses. Delays of testes descent (TD), vaginal opening (VO) and first estrus (FE) occurred at doses ≥3.75 (TD) and ≥7.5 mg/kg bw/d (VO, FE), respectively. Body weight on the days of TD, VO and FE did not differ among groups. TPT at doses ≥3.75 mg/kg decreased sperm and spermatid counts at the end of treatment (PND 46) but no alteration was noted later on PND 75. Testicular histopathology (PND 46) showed a dose-dependent reduction of seminiferous tubules diameter, a greater degree of vacuolation in Sertoli cells and germ cell degeneration and necrosis in TPT-treated mice. TPT did not affect the outcome of fertility tests. Study-derived NOAEL was 1.875 mg TPT/kg bw/d for males and 3.75 mg TPT/kg bw/d for females. The detrimental effects of TPT on spermatogenesis were reversed after treatment discontinuation.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.format.extent405-414
dc.language.isoeng
dc.publisherElsevier Ireland Ltd.
dc.relation.ispartofToxicology Reports
dc.sourceCurrículo Lattes
dc.subjectTriphenyltinen
dc.subjectTPTHen
dc.subjectOrganotin compoundsen
dc.subjectPubertyen
dc.subjectPostnatal exposureen
dc.subjectFertilityen
dc.titleSexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periodsen
dc.typeArtigo
dc.contributor.institutionFundação Oswaldo Cruz (Fiocruz)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal do Estado do Rio de Janeiro (UNIRIO)
dc.description.affiliationFundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, RJ, Brasil
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências de Botucatu (IBB), Departamento de Morfologia, Botucatu, SP, Brasil
dc.description.affiliationUniversidade Federal do Estado do Rio de Janeiro (UNIRIO), Departamento Bioquímica, Rio de Janeiro, RJ, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Instituto de Biociências de Botucatu (IBB), Departamento de Morfologia, Botucatu, SP, Brasil
dc.identifier.doi10.1016/j.toxrep.2014.12.006
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
dc.identifier.lattes6326450271169741
unesp.departmentMorfologiapt
unesp.author.lattes6326450271169741
dc.relation.ispartofsjr0,580
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