Parâmetros da resposta metabólica ao trauma cirúrgico induzido por mastectomia unilateral associada ou não à ovário-histerectomia em cadelas
Carregando...
Data
2016-06-17
Autores
Rodigheri, Sabrina Marin [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Resumo
O objetivo deste estudo foi avaliar a intensidade da resposta metabólica associada ao trauma induzido pela mastectomia unilateral em fêmeas da espécie canina com neoplasia mamária, assim como verificar se a ovário-histerectomia concomitante potencializa a reação orgânica ao trauma. Foram estudados sete momentos do período perioperatório de 11 cadelas com neoplasia mamária submetidas à mastectomia unilateral (Grupo 1) e 11 submetidas à mastectomia unilateral e ovário-histerectomia (Grupo 2). Os parâmetros mensurados foram: frequência cardíaca, frequência respiratória, pressão arterial sistólica, temperatura corporal e níveis sanguíneos de glicose, lactato, albumina, fibrinogênio, cortisol, interleucina 2, interleucina 6 e fator de necrose tumoral alfa. O tempo de duração das cirurgias foi significativamente maior na mastectomia unilateral associada a ovário-histerectomia, entretanto, não houve correlação entre o tempo cirúrgico e os parâmetros avaliados. Foi observada redução significativa da frequência respiratória, pressão arterial sistólica e temperatura corporal ao término de ambas cirurgias, sendo a redução da frequência respiratória mais intensa nas fêmeas submetidas a mastectomia unilateral e ovário-histerectomia. O trauma cirúrgico promoveu redução nas concentrações séricas de albumina e interleucina 2 e aumento nos níveis sanguíneos de glicose e interleucina 6 no período pós-operatório dos pacientes dos grupos 1 e 2. Constatou-se aumento dos níveis séricos de cortisol após o término da mastectomia unilateral associada a ovário-histerectomia. A análise dos resultados do presente estudo permite concluir que a mastectomia unilateral induz alterações metabólicas significativas em cadelas com neoplasias mamárias. A realização da ovário-histerectomia no mesmo tempo cirúrgico potencializa a resposta orgânica ao trauma.
The objective of this study was to evaluate the intensity of the metabolic response associated with trauma induced by unilateral mastectomy in bitches with mammary tumors, as well as verify if the realization of ovariohisterectomy during surgery enhances the organic reaction to trauma. It were evaluated seven moments in the perioperative period of 11 bitches with mammary tumors subjected to unilateral mastectomy (Group 1) and 11 to unilateral mastectomy and ovariohysterectomy (Group 2). The parameters that were measured included: heart rate, breathing rate, systolic blood pressure, body temperature and blood levels of glucose, lactate, albumin, fibrinogen, cortisol, interleukin 2, interleukin 6 and tumor necrosis factor alpha. Surgical duration was significantly higher in unilateral mastectomy associated with ovariohysterectomy, however, there was no correlation between the surgical time and the parameters evaluated. There was a significant reduction in respiratory rate, systolic blood pressure and body temperature at the end of both surgeries, and the reduction of the respiratory rate was more intense in females undergoing unilateral mastectomy and ovariohysterectomy. Surgical trauma promoted reduction in serum albumin and interleukin 2 levels and increased blood levels of glucose and interleukin 6 in the postoperative period of patients in groups 1 and 2. It found increased serum cortisol levels after the unilateral mastectomy associated with ovariohysterectomy. The analysis of this study results shows that unilateral mastectomy induces significant metabolic changes in dogs with mammary tumors. The realization of ovariohysterectomy during surgery enhances the organic response to trauma.
The objective of this study was to evaluate the intensity of the metabolic response associated with trauma induced by unilateral mastectomy in bitches with mammary tumors, as well as verify if the realization of ovariohisterectomy during surgery enhances the organic reaction to trauma. It were evaluated seven moments in the perioperative period of 11 bitches with mammary tumors subjected to unilateral mastectomy (Group 1) and 11 to unilateral mastectomy and ovariohysterectomy (Group 2). The parameters that were measured included: heart rate, breathing rate, systolic blood pressure, body temperature and blood levels of glucose, lactate, albumin, fibrinogen, cortisol, interleukin 2, interleukin 6 and tumor necrosis factor alpha. Surgical duration was significantly higher in unilateral mastectomy associated with ovariohysterectomy, however, there was no correlation between the surgical time and the parameters evaluated. There was a significant reduction in respiratory rate, systolic blood pressure and body temperature at the end of both surgeries, and the reduction of the respiratory rate was more intense in females undergoing unilateral mastectomy and ovariohysterectomy. Surgical trauma promoted reduction in serum albumin and interleukin 2 levels and increased blood levels of glucose and interleukin 6 in the postoperative period of patients in groups 1 and 2. It found increased serum cortisol levels after the unilateral mastectomy associated with ovariohysterectomy. The analysis of this study results shows that unilateral mastectomy induces significant metabolic changes in dogs with mammary tumors. The realization of ovariohysterectomy during surgery enhances the organic response to trauma.
Descrição
Palavras-chave
Oncologia, Cirurgia oncológica, Trauma cirúrgico, Neoplasia mamária, Cães, Oncology, Surgical oncology, Surgical trauma, Mammary tumor, Dogs