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dc.contributor.advisorLima, Valéria Marçal Felix de [UNESP]
dc.contributor.authorVenturin, Gabriela Lovizutto [UNESP]
dc.date.accessioned2016-09-27T13:39:59Z
dc.date.available2016-09-27T13:39:59Z
dc.date.issued2015-12-04
dc.identifier.citationVENTURIN, Gabriela Lovizutto. Níveis de arginase, óxido nítrico e o efeito da pge2 na produção de tnf-α em linfonodo de cães com leishmaniose visceral. 2015. 59 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2015.
dc.identifier.urihttp://hdl.handle.net/11449/144048
dc.description.abstractVisceral leishmaniasis (VL) is a chronic disease that can be fatal to humans and dogs. The disease is caused by the intracellular parasite Leishmania infantum and is transmitted by the bite of the sandfly (phlebotomines). In dogs, VL is observed as an intense chronic inflammatory reaction in the liver, spleen, skin, bone marrow and lymph nodes. Arginase activity is important in VL because an increase of this enzyme may contribute to the multiplication of the parasite and a reduction of nitric oxide (NO) synthesis, predisposing a macrophage to infection. Prostaglandin E2 (PGE2) can play a regulatory role in the production of tumor necrosis factor (TNF-α) and interleukin-10 (IL-10), however, there have been no studies in dogs with LV. This study aimed to evaluate the arginase activity in adherent macrophages cultivated from the lymph nodes of 18 healthy and 23 naturally infected dogs and to examine levels of NO and PGE2 in the supernatant of these cultures. The regulatory effect of PGE2 on the production of TNF-α and IL-10 was also evaluated in supernatants of total lymph node leukocytes cultures. These results help to clarify the mechanisms of the immune response in CVL.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent59 f.
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (UNESP)
dc.sourceAleph
dc.subjectCãespt
dc.subjectLeishmaniose visceralpt
dc.subjectLeishmaniapt
dc.subjectZoonosespt
dc.subjectOxido nítricopt
dc.subjectGânglios linfáticospt
dc.subjectFator de necrose de tumorpt
dc.subjectIndomethacinpt
dc.titleNíveis de arginase, óxido nítrico e o efeito da pge2 na produção de tnf-α em linfonodo de cães com leishmaniose visceralpt
dc.typeDissertação de mestrado
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2013/066849
unesp.graduateProgramCiência Animal - FMVApt
unesp.knowledgeAreaMedicina Veterinária Preventiva e Produção Animalpt
unesp.researchAreaepidemiologia, etiopatogenia, diagnostico e controle das enfermidades dos animaispt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatubapt
dc.identifier.aleph000870615
dc.identifier.file000870615.pdf
dc.identifier.capes33004021075P8
dc.identifier.lattes4875352337860036
unesp.author.lattes4875352337860036
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