Montagem dos genomas e anotação das proteínas de Leishmania (Viannia) guyanensis e Leishmania (Viannia) shawi
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Data
2016-12-09
Autores
Athayde, Flávia Regina Florencio de [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
Os protozoários do gênero Leishmania, da família Trypanosomatidae, são responsáveis por causar as leishmanioses, zoonoses de distribuição mundial que atingem países de regiões tropicais e subtropicais, representando um importante problema de saúde pública. As espécies de Leishmania patogênicas à humanos são classificadas em dois subgêneros, Leishmania e Viannia, sendo responsáveis pelas três formas clínicas mais comuns da doença. O subgênero Leishmania tem representantes no Velho e no Novo Mundo, enquanto que as espécies do subgênero Viannia estão presentes somente nas regiões tropicais das Américas, sendo responsáveis pela manifestação tegumentar na forma cutânea e mucocutânea. O avanço nas tecnologias de sequenciamento e montagem dos genomas de espécies de Leishmania têm possibilitado melhor entendimento das leishmanioses, da relação parasita-hospedeiro e até mesmo a identificação diferencial das espécies, auxiliando no entendimento das diferenças nas manifestações clínicas. Com o intuito de ampliar as informações genômicas das espécies de Leishmania e do subgênero Viannia, trabalhamos com o sequenciamento de DNA genômico e ferramentas de bioinformática para a montagem do genoma e anotação de proteínas de duas espécies, Leishmania (Viannia) guyanensis e Leishmania (Viannia) shawi.
The protozoa of the Trypanosomatidae family Leishmania genus, are responsible for causing leishmaniosis, zoonosis of global distribution that affects countries in tropical and subtropical regions, representing an important public health problem. The Leishmania species pathogenic to humans are classified into two subgenera, Leishmania and Viannia, which are responsible for three of the most common clinical manifestations of this disease. The subgenus Leishmania has representatives in the Old and New World, while the Viannia species are present only in the tropical regions of the Americas. These are responsible for the tegumentary manifestation of the cutaneous and mucocutaneous forms. The advance in the technologies of sequencing and the assembly of the genomes of Leishmania species have allowe to better understand the leishmaniosis, the parasite-host relationship and even the differential identification of the species thus, helping to understand the differences in the clinical manifestations. In order to expand the genomic information of the Leishmania species and the subgenus Viannia, we worked with genomic DNA sequencing and bioinformatics tools for assembling the genome and annotating proteins of two species, Leishmania (Viannia) guyanensis and Leishmania (Viannia) shawi.
The protozoa of the Trypanosomatidae family Leishmania genus, are responsible for causing leishmaniosis, zoonosis of global distribution that affects countries in tropical and subtropical regions, representing an important public health problem. The Leishmania species pathogenic to humans are classified into two subgenera, Leishmania and Viannia, which are responsible for three of the most common clinical manifestations of this disease. The subgenus Leishmania has representatives in the Old and New World, while the Viannia species are present only in the tropical regions of the Americas. These are responsible for the tegumentary manifestation of the cutaneous and mucocutaneous forms. The advance in the technologies of sequencing and the assembly of the genomes of Leishmania species have allowe to better understand the leishmaniosis, the parasite-host relationship and even the differential identification of the species thus, helping to understand the differences in the clinical manifestations. In order to expand the genomic information of the Leishmania species and the subgenus Viannia, we worked with genomic DNA sequencing and bioinformatics tools for assembling the genome and annotating proteins of two species, Leishmania (Viannia) guyanensis and Leishmania (Viannia) shawi.
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Genômica, Leishmaniose, Saúde pública, Trypanosoma, Genomics, Leishmaniosis, Public health