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dc.contributor.authorLuvizuto, Eloa R. [UNESP]
dc.contributor.authorDias, Sheila S. M. D. [UNESP]
dc.contributor.authorOkamoto, Tetuo
dc.contributor.authorDornelles, Rita Cassia Menegati [UNESP]
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.date.accessioned2013-09-30T18:29:49Z
dc.date.accessioned2014-05-20T13:42:59Z
dc.date.available2013-09-30T18:29:49Z
dc.date.available2014-05-20T13:42:59Z
dc.date.issued2011-10-01
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2011.03.015
dc.identifier.citationArchives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 56, n. 10, p. 984-990, 2011.
dc.identifier.issn0003-9969
dc.identifier.urihttp://hdl.handle.net/11449/14955
dc.description.abstractObjective: To investigate the expression of OPG, RANKL and TRAP during alveolar healing process (7, 14, 21, 28 and 42 postoperative days) in ovariectomized rats treated with raloxifene or with oestrogen replacement therapy, using immunohistochemistry reaction approach.Materials and methods: Wistar female rats (10 weeks age) were submitted to ovariectomy surgery (OVX) or sham surgery. The female rats were divided in four groups: (1) sham; (2) OVX/O (ovariectomy and oil); (3) OVX/E2 (ovariectomy and oestrogen replacement); (4) OVX/RLX (ovariectomy and raloxifene therapy).Results: It was observed high amount of OPG immunolabelling with predominance at 14 and 21 postoperative days on sham and OVX/RLX groups, respectively. At 7 postoperative days, there was no difference between the groups for TRAP protein. Otherwise, to the other periods, it was observed greater expression of TRAP and RANKL protein on OVX/O group compared to sham, OVX/E2 and OVX/RLX groups. It was also observed a discrete TRAP immunolabelling at 28 and 42 postoperative days on OVX/RLX group.Conclusions: Oestrogen deficiency induces osteoclastogenesis in the alveolar healing process. Quantitative changes in the osteoclastic activity could be prevented through the raloxifene therapy. (C) 2011 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent984-990
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofArchives of Oral Biology
dc.sourceWeb of Science
dc.subjectRaloxifeneen
dc.subjectBoneen
dc.subjectOsteoporosisen
dc.subjectOestrogenen
dc.subjectAlveolar healing processen
dc.subjectTRAPen
dc.subjectRANKLen
dc.subjectOPGen
dc.subjectOvariectomyen
dc.subjectOsteoclastsen
dc.subjectOsteoblastsen
dc.titleRaloxifene therapy inhibits osteoclastogenesis during the alveolar healing process in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Sagrado Coracao USC Bauru, Dept Res & Post Grad, Bauru, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Aracatuba Dent Sch, Dept Surg & Integrated Clin, Jaboticabal, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Aracatuba Dent Sch, Dept Basic Sci, Jaboticabal, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Aracatuba Dent Sch, Dept Surg & Integrated Clin, Jaboticabal, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Aracatuba Dent Sch, Dept Basic Sci, Jaboticabal, Brazil
dc.identifier.doi10.1016/j.archoralbio.2011.03.015
dc.identifier.wosWOS:000296112200007
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 04/07562-5
dc.description.sponsorshipIdFAPESP: 05/51367-5
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
dc.identifier.fileWOS000296112200007.pdf
dc.identifier.lattes0169955363968097
dc.identifier.lattes5435902422784889
dc.identifier.lattes1566928219828056
unesp.author.lattes0169955363968097
unesp.author.lattes5435902422784889
unesp.author.lattes1566928219828056
unesp.author.orcid0000-0002-6773-6966[5]
unesp.author.orcid0000-0003-0783-6612[4]
dc.relation.ispartofjcr2.050
dc.relation.ispartofsjr0,752
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