Efeitos da atividade física sobre a memória e estresse oxidativo plasmático e hipocampal de ratas na senescência
Carregando...
Data
2017-07-25
Autores
Ramires, Maria Luiza Gregolin [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Resumo
Há evidências que a prática regular de atividade física potencializa a memória, diminui o estresse oxidativo plasmático e hipocampal e a ansiedade na senescência. Neste trabalho foram utilizadas 40 ratas (Rattus norvegicus albinus, Wistar), com 13 meses de idade ao início do experimento, divididas em quatro grupos: um grupo controle (GC) e três grupos tratamento (GT1, GT2 e GT3), sendo 10 animais em cada grupo. O grupo controle foi mantido apenas sob observação. Aos grupos tratamento foram aplicados exercícios físicos e de memória, sendo que ao GT1, apenas exercícios de memória; ao GT2 escalada em escada, e ao GT3 ambos os exercícios. Os animais que foram submetidos à escalada em escada três vezes por semana durante três meses consecutivos e aos testes de memória, apresentaram melhor desempenho nas memórias de curto e longo prazo e de habituação, bem como menor ansiedade em teste de campo aberto. A baixa concentração de malonaldeído (MDA), o equilíbrio da superóxido dismutase (SOD) e o aumento da capacidade antioxidante total (Ferric Reducing Antioxidant Power- FRAP, foram observados nas amostras plasmáticas e hipocampais de ratas submetidas aos tratamentos. Concluiu-se que a prática de exercício físico regular associado a exercícios de memória melhorou as capacidades mnemônicas, diminuiu o estresse oxidativo e a ansiedade de ratas na senescência.
There is evidence that regular physical activity enhances memory, decreases plasma and hippocampal oxidative stress, and anxiety in senescence. In this work, 40 rats (Rattus norvegicus albinus, Wistar), 13 months old at the start of the experiment, were divided into four groups: one control group (CG) and three treatment groups (GT1, GT2 and GT3), 10 animals in each group. The control group was kept under observation only. In the treatment groups, physical and memory exercises were applied, and to GT1, only memory exercises; to GT2 climbing stairs, and to GT3 both exercises. Animals that underwent ladder climbing three times a week for three consecutive months and memory tests showed better performance in short and long term memory and habituation as well as lower anxiety in the open field test. The low concentration of malonaldehyde (MDA), the balance of superoxide dismutase (SOD) and the increase in total antioxidant capacity (Ferric Reducing Antioxidant Power - FRAP) were observed in the plasma and hippocampal samples of rats submitted to treatments. Regular exercise practice associated with memory exercises improved mnemonic abilities, decreased oxidative stress and anxiety of rats in senescence.
There is evidence that regular physical activity enhances memory, decreases plasma and hippocampal oxidative stress, and anxiety in senescence. In this work, 40 rats (Rattus norvegicus albinus, Wistar), 13 months old at the start of the experiment, were divided into four groups: one control group (CG) and three treatment groups (GT1, GT2 and GT3), 10 animals in each group. The control group was kept under observation only. In the treatment groups, physical and memory exercises were applied, and to GT1, only memory exercises; to GT2 climbing stairs, and to GT3 both exercises. Animals that underwent ladder climbing three times a week for three consecutive months and memory tests showed better performance in short and long term memory and habituation as well as lower anxiety in the open field test. The low concentration of malonaldehyde (MDA), the balance of superoxide dismutase (SOD) and the increase in total antioxidant capacity (Ferric Reducing Antioxidant Power - FRAP) were observed in the plasma and hippocampal samples of rats submitted to treatments. Regular exercise practice associated with memory exercises improved mnemonic abilities, decreased oxidative stress and anxiety of rats in senescence.
Descrição
Palavras-chave
Atividade motora, Cognição, Capacidade antioxidante, MDA, Hipocampo, Motor activity, Ceognition, Antioxidant capacity, Hippocampus