Efeito do exercício físico aquático de baixa, média e alta intensidade na artrite induzida em joelho de ratos Wistar
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Data
2018-05-30
Autores
Mioto, Alline Mardegan [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
A artrite reumatoide (AR) é uma doença inflamatória crônica, autoimune e de etiologia e patogênese desconhecidas que afeta o sistema musculoesquelético. O exercício físico é indicado como meio de auxiliar a retardar a incapacidade funcional, ajudando a melhorar a função articular. OBJETIVO: O objetivo desse estudo foi analisar os efeitos que exercício físico aquático ─ nas intensidades baixa, média e alta ─ provocam na inflamação articular, nas propriedades dos ossos, fêmur e tíbia, na artrite induzida em joelhos de ratos. MÉTODOS: Foram utilizados 20 ratos machos Wistar com 60 dias de idade, divididos em 5 grupos: Grupo Controle Artrite (GCA) n= 4, Grupo Controle Placebo (GCP) n=4, Grupo Atividade física baixa (GB) n=4, grupo Atividade Física Moderada (GM) n=4 e grupo Atividade Física Intensa (GI) n=4. Os grupos de atividade física foram submetidos à injeção intraarticular (ia) de 0,05 ml/100g Zymosam (1mg/50µL) no joelho direito. Os animais do grupo controle artrite (GCA) receberam solução salina no joelho direito ao invés do Zymosan, e os animais do grupo controle placebo (GCP) foram submetidos somente ao estresse da agulha. Os animais foram submetidos à atividade aquática durante 30 minutos, 4 vezes na semana, durante 5 semanas, sendo a intensidade do exercício determinada por meio da sobrecarga colocada no dorso de cada animal em seus respectivos grupos: GB 1%, GM 5%, GI 15% do peso do rato, no grupo GCA não foi adicionada sobrecarga. Os animais foram eutanasiados após 5 semanas de treinamento. RESULTADOS: Observou-se que o grupo de baixa intensidade, e os grupos que não fizeram exercício GCA e GCP, ganharam mais peso comparado ao grupo de média intensidade GM. Em relação ao edema articular houve diminuição do mesmo no grupo GI após a terceira semana de treino e no grupo GM após a 4º semana de exercício, já em relação ao conteúdo mineral ósseo (CMO) da tíbia houve diminuição do grupo GM quando comparado ao grupo GCP (p=0,026), já na densidade mineral óssea da tíbia houve diminuição do grupo GM comparado aos grupos GCP (p=0,001), GCA (p=0,002), GB (p=0,026). Para Área do fêmur, o grupo GI apresentou aumento comparado aos grupos GB (p=0,014) e GM (p=0,008). CONCLUSÃO: conclui-se que os exercício de intensidade moderada e alta intensidade promovem melhores resultados que os exercícios de baixa intensidade.
Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease, its etiology and pathogenesis are unknown and it affects the musculoskeletal system. Based on this argument, physical exercise is indicated as it may help to delay functional disability, which can improve joint function. OBJECTIVE: The aim of this study was to analyze the effects of aquatic physical exercise on the low, medium and high intensity on the joint inflammation and on the properties of femoral and tibial bones of the rats in which knee arthritis was induced. METHODS: Twenty male Wistar rats aged 60 days were divided into 5 groups: Group Control Arthritis (GCA) n = 4, Group Control Placebo (GCP) n = 4, Group Low physical activity (GL) n = 4, Group Moderate physical activity (GM) n = 4 and Group Intense Physical activity (GI) n = 4. The physical activity groups were submitted to intra-articular injection (ai) of 0.05 ml / 100g Zymosam (1mg / 50μL) in the right knee. The animals in the control group arthritis (GCA) received saline solution in the right knee instead of Zymosan, and the animals in the placebo control group (GCP) were submitted only to the stress of the needle. The animals were submitted to aquatic activity for 30 minutes, 4 times a week for 5 weeks, and the intensity of the exercise was determined by the overload placed on the back of each animal in their respective groups: GL 1%, GM 5%, GI 15 % of their weight, no overload was added in the GCA group. The animals were euthanized after 5 weeks of training RESULTS:It was observed that the low intensity group GL, and the groups that did not exercise GCA and GCP, gained more weight compared to the group GM. In relation to the joint edema, there was a decrease in the GI (p = 0.200) after the third week of training and in the GM group (p= 0.39) after In the 4th week of exercise; in relation to the bone mineral content (BMC) of the tibia, there was a decrease in the GM group when compared to the GCP group (p = 0.026), whereas in the tibial bone mineral density (BMD) there was a decrease in the GM group compared to the GCP (p = 0.001), GCA (p = 0.002), GB (p = 0.026). As for the area of the femur, the GI group presented an increase of it compared to the GB (p = 0.014) and GM (p = 0.008) groups;. CONCLUSION: Therefore, it is concluded that the exercises of moderate intensity and high intensity promote better results than the exercises of low intensity.
Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease, its etiology and pathogenesis are unknown and it affects the musculoskeletal system. Based on this argument, physical exercise is indicated as it may help to delay functional disability, which can improve joint function. OBJECTIVE: The aim of this study was to analyze the effects of aquatic physical exercise on the low, medium and high intensity on the joint inflammation and on the properties of femoral and tibial bones of the rats in which knee arthritis was induced. METHODS: Twenty male Wistar rats aged 60 days were divided into 5 groups: Group Control Arthritis (GCA) n = 4, Group Control Placebo (GCP) n = 4, Group Low physical activity (GL) n = 4, Group Moderate physical activity (GM) n = 4 and Group Intense Physical activity (GI) n = 4. The physical activity groups were submitted to intra-articular injection (ai) of 0.05 ml / 100g Zymosam (1mg / 50μL) in the right knee. The animals in the control group arthritis (GCA) received saline solution in the right knee instead of Zymosan, and the animals in the placebo control group (GCP) were submitted only to the stress of the needle. The animals were submitted to aquatic activity for 30 minutes, 4 times a week for 5 weeks, and the intensity of the exercise was determined by the overload placed on the back of each animal in their respective groups: GL 1%, GM 5%, GI 15 % of their weight, no overload was added in the GCA group. The animals were euthanized after 5 weeks of training RESULTS:It was observed that the low intensity group GL, and the groups that did not exercise GCA and GCP, gained more weight compared to the group GM. In relation to the joint edema, there was a decrease in the GI (p = 0.200) after the third week of training and in the GM group (p= 0.39) after In the 4th week of exercise; in relation to the bone mineral content (BMC) of the tibia, there was a decrease in the GM group when compared to the GCP group (p = 0.026), whereas in the tibial bone mineral density (BMD) there was a decrease in the GM group compared to the GCP (p = 0.001), GCA (p = 0.002), GB (p = 0.026). As for the area of the femur, the GI group presented an increase of it compared to the GB (p = 0.014) and GM (p = 0.008) groups;. CONCLUSION: Therefore, it is concluded that the exercises of moderate intensity and high intensity promote better results than the exercises of low intensity.
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Palavras-chave
Artrite reumatóide, Exercício físico, Ratos, Artrite induzida em ratos, Rheumatoid arthritis, Physical exercise, Mice, Physiotherapy, Induced arthritis