Desenvolvimento e caracterização de nanocápsulas de poli (L-lactídeo) contendo benzocaína

doi:10.1590/S0100-40422010000100013

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Alternative title

Development and characterization of poli (L-lactide) nanocapsules containing benzocaine

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https://orcid.org/0000-0002-2042-018X

Date

2010-01-01

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Article

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http://dx.doi.org/10.1590/S0100-40422010000100013

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Abstract

In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of -38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.

How to cite this document

Melo, Nathalie Ferreira Silva de et al. Desenvolvimento e caracterização de nanocápsulas de poli (L-lactídeo) contendo benzocaína. Química Nova. Sociedade Brasileira de Química, v. 33, n. 1, p. 65-69, 2010. Available at: <http://hdl.handle.net/11449/156>.