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dc.contributor.authorGuimaraes, Morgana R. [UNESP]
dc.contributor.authorde Aquino, Sabrina Garcia [UNESP]
dc.contributor.authorCoimbra, Leila S. [UNESP]
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.authorKirkwood, Keith L.
dc.contributor.authorRossa, Carlos [UNESP]
dc.date.accessioned2013-09-30T18:32:31Z
dc.date.accessioned2014-05-20T13:45:14Z
dc.date.available2013-09-30T18:32:31Z
dc.date.available2014-05-20T13:45:14Z
dc.date.issued2012-02-01
dc.identifierhttp://dx.doi.org/10.1177/1753425910392935
dc.identifier.citationInnate Immunity. London: Sage Publications Ltd, v. 18, n. 1, p. 155-163, 2012.
dc.identifier.issn1753-4259
dc.identifier.urihttp://hdl.handle.net/11449/15902
dc.description.abstractCurcumin is a plant-derived dietary spice ascribed various biological activities. Curcumin therapeutic applications have been studied in a variety of conditions, but not on periodontal disease. Periodontal disease is a chronic inflammatory condition initiated by an immune response to micro-organisms of the dental biofilm. Experimental periodontal disease was induced in rats by injecting LPS in the gingival tissues on the palatal aspect of upper first molars (30 mu g LPS, 3 times/week for 2 weeks). Curcumin was administered to rats daily via oral gavage at 30 and 100 mg/kg body weight. Reverse transcriptase-qPCR and ELISA were used to determine the expression of IL-6, TNF-alpha and prostaglandin E-2 synthase on the gingival tissues. The inflammatory status was evaluated by stereometric and descriptive analysis on hematoxylin/eosin-stained sections, whereas modulation of p38 MAPK and NK-kappa B signaling was assessed by Western blot. Curcumin effectively inhibited cytokine gene expression at mRNA and protein levels, but NF-kappa B was inhibited only with the lower dose of curcumin, whereas p38 MAPK activation was not affected. Curcumin produced a significant reduction on the inflammatory infiltrate and increased collagen content and fibroblastic cell numbers. Curcumin potently inhibits innate immune responses associated with periodontal disease, suggesting a therapeutic potential in this chronic inflammatory condition.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipNational Institutes of Health - National Institute of Dental and Craniofacial Research (NIH/NIDCR)
dc.format.extent155-163
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofInnate Immunity
dc.sourceWeb of Science
dc.subjectCurcuminen
dc.subjectinflammationen
dc.subjectinnate immunityen
dc.subjectperiodontal diseaseen
dc.titleCurcumin modulates the immune response associated with LPS-induced periodontal disease in ratsen
dc.typeArtigo
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderSage Publications Ltd
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionMed Univ S Carolina
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Odontol Araraquara, Dept Diag & Surg, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Odontol Araraquara, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationMed Univ S Carolina, Coll Dent Med, Dept Craniofacial Biol, Charleston, SC 29425 USA
dc.description.affiliationMed Univ S Carolina, Coll Dent Med, Ctr Oral Hlth, Charleston, SC 29425 USA
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Odontol Araraquara, Dept Diag & Surg, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Odontol Araraquara, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.identifier.doi10.1177/1753425910392935
dc.identifier.wosWOS:000299162600014
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdCAPES: 4638-05
dc.description.sponsorshipIdNIH/NIDCR: 1R01DE018290
dc.description.sponsorshipIdNIH/NIDCR: P20RR017696
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
dc.identifier.lattes2640929291808415
unesp.author.lattes2640929291808415
unesp.author.orcid0000-0002-3988-1939[2]
unesp.author.orcid0000-0003-1705-5481[6]
unesp.author.orcid0000-0002-0592-542X[4]
unesp.author.orcid0000-0002-1297-9717[1]
dc.relation.ispartofjcr2.312
dc.relation.ispartofsjr1,031
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