Evaluation of chitosan gel as antibiotic and photosensitizer delivery
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Data
2008-01-01
Autores
Fontana, Carla Raquel [UNESP]
dos Santos Junior, David Sotero
Bosco, Joseane Maria
Spolidorio, Denise M. [UNESP]
Marcantonio, Rosemary Adriana Chierici [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Informa Healthcare
Resumo
This work suggests the use of chitosan gel imbued with the photosensitizer Photogem and with the antibiotic Tetraclin as a possible drug delivery system. The results reveal a decrease in the photosensitizer level of toxicity. Besides, the interaction between Photogem and chitosan gel causes a red shift in the photosensitizer spectrum, increasing its absorption in the therapeutic window (600-700 nm). These characteristics indicate this compound as a promising natural polymer-based photosensitizer carrier for photodynamic therapy. In summary, our results show that pure and doped chitosan gel may have potential application for antimicrobial action, being an excellent alternative when local control of the drug administration, provided by the gel, is required.
Descrição
Palavras-chave
antimicrobial, chitosan, chitin, drug release, less toxicity, photosensitizer, spectroscopy
Como citar
Drug Delivery. London: Informa Healthcare, v. 15, n. 7, p. 417-422, 2008.