Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
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Data
2017-04-01
Autores
Ghezzi, Silvia
Cooper, Lynsay
Rubio, Alicia
Pagani, Isabel
Capobianchi, Maria Rosaria
Ippolito, Giuseppe
Pelletier, Julien [UNESP]
Meneghetti, Maria Cecilia Z.
Lima, Marcelo A.
Skidmore, Mark A.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). (C) 2017 Elsevier B.V. All rights reserved.
Descrição
Palavras-chave
Zika virus (ZIKV), Neural progenitor cells, Heparin, Cell death
Como citar
Antiviral Research. Amsterdam: Elsevier Science Bv, v. 140, p. 13-17, 2017.