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dc.contributor.authorTschoppe, Peter
dc.contributor.authorZandim-Barcelos, Daniela Leal [UNESP]
dc.contributor.authorSampaio, José Eduardo Cezar [UNESP]
dc.contributor.authorKielbassa, Andrej M.
dc.identifier.citationJournal of Dentistry. Oxford: Elsevier B.V., v. 38, n. 3, p. 207-213, 2010.
dc.description.abstractObjectives: The aim of this in vitro study was to assess the effects of saliva substitutes (modified with respect to calcium, phosphates, and fluorides) in combination with a high-concentrated fluoride toothpaste on demineralised dentin.Methods: Before and after demineralisation of bovine dentin specimens (subsurface lesions; 37 degrees C, pH 5.0, 5 d), one-quarter of each specimen's surface was covered with nail varnish (control of sound/demineralised tissue). Subsequently, specimens were exposed to original Saliva natura (saturation with respect to octacalciumphosphate [S(OCP)]: 0.03; SN 0), or to three lab-produced Saliva natura modifications (S(OCP): 1, 2, and 3; SN 1-3) for 2 and 5 weeks (37 degrees C). An aqueous solution (S(OCP): 2.5) served as positive control (PC). Two times daily (2 min each), Duraphat toothpaste (5000 ppm F(-); Colgate)/saliva substitute slurry (ratio 1:3) was applied gently. Differences in mineral losses (Delta Delta Z) and lesion depths (Delta LD) between values before and after exposure were microradiographically evaluated.Results: After both treatment periods specimens immersed in SN 0 revealed significantly higher mineral losses (lower Delta Delta Z values) and lesion depths (lower Delta LD) compared to PC (p < 0.05; ANOVA). After 5 weeks, specimens stored in SN 1 and 2 showed significantly higher mineral losses compared to PC (p < 0.05), while those stored in SN 3 showed similar results (p > 0.05). No differences in mineral loss could be observed between SN 2 and 3 (p > 0.05).Conclusions: Under the conditions of this limited protocol, the combination of Saliva natura solutions slightly saturated with respect to OCP in combination with a high-concentrated fluoride toothpaste enabled remineralisation of dentin in vitro. Crown Copyright (c) 2009 Published by Elsevier Ltd. All rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Dentistry
dc.sourceWeb of Science
dc.subjectIn vitroen
dc.subjectBovine dentinen
dc.subjectFluoridated toothpasteen
dc.subjectSaliva substituteen
dc.subjectOctacalcium phosphate saturationen
dc.titleSaliva substitute in combination with high-concentrated fluoride toothpaste: Effects on demineralised dentin in vitroen
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationCharite, ChariteCtr 3, Univ Sch Dent Med, Dept Operat Dent & Periodontol, D-14197 Berlin, Germany
dc.description.affiliationSão Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, São Paulo, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
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