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dc.contributor.authorFerreira, Amanda O.
dc.contributor.authorVasconcelos, Bruno G.
dc.contributor.authorFavaron, Phelipe O.
dc.contributor.authorSantos, Amilton C.
dc.contributor.authorLeandro, Rafael M.
dc.contributor.authorPereira, Flavia T. V. [UNESP]
dc.contributor.authorMaria, Durvanei A.
dc.contributor.authorMiglino, Maria Angelica
dc.identifier.citationPesquisa Veterinaria Brasileira. Rio Janeiro: Revista Pesquisa Veterinaria Brasileira, v. 38, n. 1, p. 147-153, 2018.
dc.description.abstractCentral nervous system (CNS) development researches are extremely important to the most common congenital disorders and organogenesis comprehension. However, few studies show the entire developmental process during the critical period. Present research can provide data to new researches related to normal development and abnormalities and changes that occur along the CNS organogenesis, especially nowadays with the need for preliminary studies in animal models, which could be used for experimental research on the influence of viruses, such as the influence of Zika virus on the development of the neural system and its correlation with microcephaly in human newborns. Then, present study describes CNS organogenesis in cattle according to microscopic and macroscopic aspects, identifying structures and correlating to gestational period. Fourteen embryos and nine bovine fetuses at different ages were collected and analyzed. All individuals were measured in order to detect the gestational period. Bovine embryo at 17 days age has its neural tube, cranial neuropore, caudal neuropore and somites developed. After 24 days of development, were observed in cranial part of neural tube five encephalic vesicles denominated: telencephalon, diencephalon, mesencephalon, metencephalon and myelencephalon. In addition, the caudal part of neural tube was identified with the primitive spinal cord. The primordial CNS differentiation occurred from 90 to 110 days. The five encephalic vesicles, primordial spinal cord and the cavities: third ventricule, mesencephalic aqueduct, fourth ventricle and central canal in spinal cord were observed. With 90 days, the main structures were identified: (1) cerebral hemispheres, corpus callosum and fornix, of the telencephalon; (2) interthalamic adhesion, thalamus, hypothalamus and epythalamus (glandula pinealis), of the diencephalon; (3) cerebral peduncles and quadruplets bodies, of the mesencephalon; (4) pons and cerebellum, of the metencephalon; (5) medulla oblongata or bulb, of the myelencephalon; and (6) spinal cord, of the primitive spinal cord. After 110 days of gestation, the five encephalic vesicles and its structures were completely developed. It was noted the presence of the spinal cord with the cervicothoracic and lumbossacral intumescences. In summary, the results describes the formation of the neural tube from the neural plate of the ectoderm, the encephalic vesicles derived from the neural tube and subsequent structural and cavities subdivisions, thus representing the complete embryology of the central nervous system.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.publisherRevista Pesquisa Veterinaria Brasileira
dc.relation.ispartofPesquisa Veterinaria Brasileira
dc.sourceWeb of Science
dc.subjectBovine central nervous system
dc.subjectencephalic vesicles
dc.subjectspinal cord
dc.titleBovine central nervous system developmenten
dcterms.rightsHolderRevista Pesquisa Veterinaria Brasileira
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Sao Paulo, Fac Med Vet & Zootecnia, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Vales Jequitinhonha & Mucuri, Inst Ciencias Agr, Av Vereador Joao Narciso 1380, BR-38610000 Unai, MG, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquita Filho Un, Campus Dracena, BR-17900000 Dracena, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquita Filho Un, Campus Dracena, BR-17900000 Dracena, SP, Brazil
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