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dc.contributor.authorViana, Aline C. [UNESP]
dc.contributor.authorKim, Yeon J. [UNESP]
dc.contributor.authorCurtis, Karen M. C. [UNESP]
dc.contributor.authorRenzi, Rivelto [UNESP]
dc.contributor.authorOrrico, Silvana Regina Perez [UNESP]
dc.contributor.authorCirelli, Joni Augusto [UNESP]
dc.contributor.authorScarel-Caminaga, Raquel M. [UNESP]
dc.date.accessioned2014-05-20T13:45:34Z
dc.date.available2014-05-20T13:45:34Z
dc.date.issued2010-04-01
dc.identifierhttp://dx.doi.org/10.1089/dna.2009.0919
dc.identifier.citationDna and Cell Biology. New Rochelle: Mary Ann Liebert Inc., v. 29, n. 4, p. 191-200, 2010.
dc.identifier.issn1044-5498
dc.identifier.urihttp://hdl.handle.net/11449/16039
dc.description.abstractCXCR-2 is a receptor of interleukin-8, which is involved in acute and chronic inflammatory processes. Polymorphisms in the CXCR2 gene have been associated with chronic inflammatory conditions. The aim of this study was to investigate whether the +785(C/T), +1208(T/C), and +1440(G/A) single-nucleotide polymorphisms (SNPs) in the CXCR2 gene, as well as their haplotypes, are associated with susceptibility to periodontitis in Brazilians. DNA was extracted from the buccal epithelial cells of 487 individuals (control 215; periodontitis 272). The SNPs were investigated using the sequence-specific primer-polymerase chain reaction method. Associations between the polymorphisms and subject phenotypes were analyzed using the chi-squared statistical test, followed by univariate and multivariate logistic regression modeling. Haplotypes were reconstructed using the expectation-maximization algorithm, and differences in haplotype distribution between the groups were analyzed to estimate genetic susceptibility for periodontitis development. Univariate and multivariate analysis revealed that age, skin color, and smoking status were associated with periodontitis. The +1440 GG genotype was shown to be protective against periodontitis in both univariate and multivariate analysis (odds ratio [OR](adjusted) = 0.42; 95% confidence interval [CI] = 0.19, 0.96). A similar relevant result for the +1440 GG was obtained in an alternative analysis considering a subgroup containing only white nonsmokers (OR = 0.37; 95% CI = 0.15, 0.92). White nonsmokers with the CTG/TCG haplotype appeared to be genetically protected against the development of periodontitis (OR = 0.29; 95% CI = 0.09, 0.89), while those carrying the CTG/TCA haplotype were more susceptible to the development of periodontitis (OR = 2.08; 95% CI = 1.24, 3.51). In conclusion, the +1440 SNP and some haplotypes are associated with periodontitis in Brazilian individuals.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent191-200
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc.
dc.relation.ispartofDna and Cell Biology
dc.sourceWeb of Science
dc.titleAssociation of Haplotypes in the CXCR2 Gene with Periodontitis in a Brazilian Populationen
dc.typeArtigo
dcterms.licensehttp://www.liebertpub.com/reprints/dna-and-cell-biology/13/
dcterms.rightsHolderMary Ann Liebert Inc.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUNESP Univ Estadual Paulista, Sch Dent Araraquara, Dept Oral Diagnost & Surg, Araraquara, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Sch Dent Araraquara, Dept Morphol, Araraquara, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Sch Dent Araraquara, Dept Oral Diagnost & Surg, Araraquara, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Sch Dent Araraquara, Dept Morphol, Araraquara, Brazil
dc.identifier.doi10.1089/dna.2009.0919
dc.identifier.wosWOS:000276421900005
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 03/10424-0
dc.description.sponsorshipIdFAPESP: 05/03231-7
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
dc.identifier.fileWOS000276421900005.pdf
dc.identifier.lattes7383391319292040
dc.identifier.lattes2628593693450121
unesp.author.lattes7383391319292040
unesp.author.lattes2628593693450121
unesp.author.orcid0000-0001-5068-0268[7]
unesp.author.orcid0000-0002-7082-9290[6]
dc.relation.ispartofjcr2.634
dc.relation.ispartofsjr0,872
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