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dc.contributor.authorDe Gobbi, JIF
dc.contributor.authorDe Luca, L. A.
dc.contributor.authorJohnson, A. K.
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.date.accessioned2014-05-20T13:45:40Z
dc.date.available2014-05-20T13:45:40Z
dc.date.issued2001-05-01
dc.identifierhttp://ajpregu.physiology.org/content/280/5/R1301
dc.identifier.citationAmerican Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 280, n. 5, p. R1301-R1307, 2001.
dc.identifier.issn0363-6119
dc.identifier.urihttp://hdl.handle.net/11449/16076
dc.description.abstractSerotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. In this study, we investigated interactions between 5-HT and CCK into the LPBN to control water and NaCl intake. Male Holtzman rats with cannulas implanted bilaterally in the LPBN were treated with furosemide + captopril to induce water and NaCl intake. Bilateral LPBN injections of high doses of the 5-HT antagonist methysergide (4 mug) or the CCK antagonist proglumide (50 mug), alone or combined, produced similar increases in water and 1.8% NaCl intake. Low doses of methysergide (0.5 mug) + proglumide (20 mug) produced greater increases in NaCl intake than when they were injected alone. The 5-HT2a/2c agonist 2,5-dimetoxy-4-iodoamphetamine hydrobromide (DOI; 5 mug) into the LPBN reduced water and NaCl intake. After proglumide (50 mug) + DOI treatment, the intake was not different from vehicle treatment. CCK-8 (1 mug) alone produced no effect. CCK-8 combined with methysergide (4 mug) reduced the effect of methysergide on NaCl intake. The data suggest that functional interactions between 5-HT and CCK in the LPBN may be important for exerting inhibitory control of NaCl intake.en
dc.format.extentR1301-R1307
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology
dc.sourceWeb of Science
dc.subject5-hydroxytryptaminept
dc.subjectproglumidept
dc.subjectmethysergidept
dc.subjectNaCl intakept
dc.subjectsodium appetitept
dc.subjectangiotensin IIpt
dc.titleInteraction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intakeen
dc.typeArtigo
dcterms.licensehttp://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright
dcterms.rightsHolderAmer Physiological Soc
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Iowa
dc.description.affiliationUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv Iowa, Dept Psychol, Iowa City, IA 52242 USA
dc.description.affiliationUniv Iowa, Dept Pharmacol & Exercise Sci, Iowa City, IA 52242 USA
dc.description.affiliationUniv Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USA
dc.description.affiliationUnespUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.identifier.wosWOS:000167973400006
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
dc.identifier.lattes1023597870118105
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-8270-2652[2]
unesp.author.orcid0000-0001-5845-0475[1]
unesp.author.orcid0000-0003-1167-4441[4]
dc.relation.ispartofjcr3.082
dc.relation.ispartofsjr1,550
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