The universal growth rate behavior and regime transition in adherent cell colonies
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Data
2015-12-21
Autores
Costa, F. H. S.
Campos, M. [UNESP]
Silva, M. A. A. da
Título da Revista
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Editor
Elsevier B.V.
Resumo
In this work, we used five cell lineages, cultivated in vitro, to show they follow a common functional form to the growth rate: a sigmoidal curve, suggesting that competition and cooperation (usual mechanisms for systems with this behavior) might be present. Both theoretical and experimental investigations, on the causes of this behavior, are challenging for the research field; since the sigmoidal form to the growth rate seems to absorb important properties of such systems, e.g., cell deformation and statistical interactions. We shed some light on this subject by showing how cell spreading affects the radius behavior of the growing colonies. Doing numerical time derivatives of the experimental data, we obtained the growth rates. Using reduced variables for the time and rates, we obtained the collapse of all colonies growth rates onto one curve with sigmoidal shape. This suggests a universal-type behavior, with regime transition related to a morphological transition of adherent cell colonies. (C) 2015 Elsevier Ltd. All rights reserved.
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Palavras-chave
Growth rate, Cancer, Mathematical model
Como citar
Journal Of Theoretical Biology. London: Academic Press Ltd- Elsevier Science Ltd, v. 387, p. 181-188, 2015.