Show simple item record

dc.contributor.authorAlves, Thales B.
dc.contributor.authorTotola, Leonardo T.
dc.contributor.authorTakakura, Ana C.
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorMoreira, Thiago S.
dc.date.accessioned2018-11-26T16:19:27Z
dc.date.available2018-11-26T16:19:27Z
dc.date.issued2016-01-01
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2015.11.001
dc.identifier.citationAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier Science Bv, v. 194, p. 1-7, 2016.
dc.identifier.issn1566-0702
dc.identifier.urihttp://hdl.handle.net/11449/161183
dc.description.abstractThe antihypertensive drugs moxonidine and clonidine are alpha(2)-adrenoceptor and imidazoline (I-1) agonists. Previous results from our laboratory have shown that moxonidine can act in the commissural nucleus of the solitary tract (commNTS). In addition, some studies have shown that GABA or glutamate receptor blockade in the RVLM blunted the hypotension produced by these antihypertensive agents in spontaneously hypertensive rats. Therefore, in the present study we verify whether the cardiovascular and sympathetic effects produced by moxonidine in the commNTS are dependent on GABAergic or glutamatergic mechanisms. Mean arterial pressure (MAP) and splanchnic sympathetic nerve activity (sSNA) were recorded in urethane-anesthetized, and artificially-ventilated male Wistar rats (250-350 g). Injection of the GABAA antagonist bicuculline (25 pmol/50 nL) into the commNTS reduced the hypotension as well as the sympathoinhibition elicited by moxonidine. Prior injection of the glutamate receptor antagonist kynurenic acid (2.5 nmo1/50 nL) into the commNTS was not effective in reducing the hypotension and sympathoinhibition elicited by moxonidine. Therefore, we conclude that the hypotensive and sympathoinhibitory effects elicited by microinjection of moxonidine into the commNTS are dependent on GABA receptors, but not ionotropic glutamate receptors. (C) 2015 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1-7
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAutonomic Neuroscience-basic & Clinical
dc.sourceWeb of Science
dc.subjectHypertension
dc.subjectCommissural NTS
dc.subjectSympathetic activity
dc.subjectMoxonidine
dc.subjectGABA
dc.titleGABA mechanisms of the nucleus of the solitary tract regulates the cardiovascular and sympathetic effects of moxonidineen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.identifier.doi10.1016/j.autneu.2015.11.001
dc.identifier.wosWOS:000369464600001
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2014/22406-1
dc.description.sponsorshipIdFAPESP: 2009/54888-7
dc.description.sponsorshipIdFAPESP: 13/10573-8
dc.description.sponsorshipIdCNPq: 471263/2013-3
dc.description.sponsorshipIdCNPq: 471283/2012-6
dc.description.sponsorshipIdCNPq: 305533/2012-6
dc.description.sponsorshipIdCNPq: 301651/2013-2
dc.description.sponsorshipIdFAPESP: 2011/11934-9
dc.identifier.fileWOS000369464600001.pdf
unesp.author.lattes4544450092427426[4]
unesp.author.orcid0000-0002-1395-4036[4]
dc.relation.ispartofsjr0,902
Localize o texto completo

Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record