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dc.contributor.authorLeopoldo, A. S.
dc.contributor.authorLima-Leopoldo, A. P.
dc.contributor.authorNascimento, A. F.
dc.contributor.authorLuvizotto, R. A. M.
dc.contributor.authorSugizaki, M. M.
dc.contributor.authorCampos, D. H. S. [UNESP]
dc.contributor.authorSilva, D. C. T. da [UNESP]
dc.contributor.authorPadovani, C. R. [UNESP]
dc.contributor.authorCicogna, A. C. [UNESP]
dc.date.accessioned2018-11-26T16:27:56Z
dc.date.available2018-11-26T16:27:56Z
dc.date.issued2016-01-01
dc.identifierhttp://dx.doi.org/10.1590/1414-431X20155028
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 49, n. 4, 9 p., 2016.
dc.identifier.issn0100-879X
dc.identifier.urihttp://hdl.handle.net/11449/161298
dc.description.abstractIn experimental studies, several parameters, such as body weight, body mass index, adiposity index, and dual-energy X-ray absorptiometry, have commonly been used to demonstrate increased adiposity and investigate the mechanisms underlying obesity and sedentary lifestyles. However, these investigations have not classified the degree of adiposity nor defined adiposity categories for rats, such as normal, overweight, and obese. The aim of the study was to characterize the degree of adiposity in rats fed a high-fat diet using cluster analysis and to create adiposity intervals in an experimental model of obesity. Thirty-day-old male Wistar rats were fed a normal (n=41) or a high-fat (n=43) diet for 15 weeks. Obesity was defined based on the adiposity index; and the degree of adiposity was evaluated using cluster analysis. Cluster analysis allowed the rats to be classified into two groups (overweight and obese). The obese group displayed significantly higher total body fat and a higher adiposity index compared with those of the overweight group. No differences in systolic blood pressure or nonesterified fatty acid, glucose, total cholesterol, or triglyceride levels were observed between the obese and overweight groups. The adiposity index of the obese group was positively correlated with final body weight, total body fat, and leptin levels. Despite the classification of sedentary rats into overweight and obese groups, it was not possible to identify differences in the comorbidities between the two groups.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent9
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.sourceWeb of Science
dc.subjectObesity
dc.subjectAdiposity index
dc.subjectRats
dc.subjectCluster analysis
dc.titleClassification of different degrees of adiposity in sedentary ratsen
dc.typeArtigo
dcterms.rightsHolderAssoc Bras Divulg Cientifica
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Fed Espirito Santo, Ctr Educ Fis & Esportes, Dept Desportos, Vitoria, ES, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Inst Ciencias Saude, Sinop, MT, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med, Dept Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Bioestat, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med, Dept Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Bioestat, Botucatu, SP, Brazil
dc.identifier.doi10.1590/1414-431X20155028
dc.identifier.scieloS0100-879X2016000400601
dc.identifier.wosWOS:000371733500002
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2007/53267-3
dc.description.sponsorshipIdFAPESP: 2006/59485-0
dc.identifier.fileS0100-879X2016000400601.pdf
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