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dc.contributor.authorMinatel, Igor Otavio [UNESP]
dc.contributor.authorFrancisqueti, Fabiane Valentini [UNESP]
dc.contributor.authorCorrea, Camila Renata [UNESP]
dc.contributor.authorPereira Lima, Giuseppina Pace [UNESP]
dc.date.accessioned2018-11-26T17:04:26Z
dc.date.available2018-11-26T17:04:26Z
dc.date.issued2016-08-01
dc.identifierhttp://dx.doi.org/10.3390/ijms17081107
dc.identifier.citationInternational Journal Of Molecular Sciences. Basel: Mdpi Ag, v. 17, n. 8, 15 p., 2016.
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11449/161863
dc.description.abstractgamma-oryzanol (Orz), a steryl ferulate extracted from rice bran layer, exerts a wide spectrum of biological activities. In addition to its antioxidant activity, Orz is often associated with cholesterol-lowering, anti-inflammatory, anti-cancer and anti-diabetic effects. In recent years, the usefulness of Orz has been studied for the treatment of metabolic diseases, as it acts to ameliorate insulin activity, cholesterol metabolism, and associated chronic inflammation. Previous studies have shown the direct action of Orz when downregulating the expression of genes that encode proteins related to adiposity (CCAAT/enhancer binding proteins (C/EBPs)), inflammatory responses (nuclear factor kappa-B (NF-kappa B)), and metabolic syndrome (peroxisome proliferator-activated receptors (PPARs)). It is likely that this wide range of beneficial activities results from a complex network of interactions and signals triggered, and/or inhibited by its antioxidant properties. This review focuses on the significance of Orz in metabolic disorders, which feature remarkable oxidative imbalance, such as impaired glucose metabolism, obesity, and inflammation.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent15
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofInternational Journal Of Molecular Sciences
dc.sourceWeb of Science
dc.subjectgamma-oryzanol
dc.subjectferulic acid
dc.subjectantioxidant capacity
dc.subjectdyslipidemia
dc.subjectobesity
dc.subjectinflammation
dc.titleAntioxidant Activity of gamma-Oryzanol: A Complex Network of Interactionsen
dc.typeResenha
dcterms.rightsHolderMdpi Ag
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationSao Paulo State Univ, Inst Biosci, Dept Chem & Biochem, BR-18618689 Botucatu, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Botucatu Med Sch, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Inst Biosci, Dept Chem & Biochem, BR-18618689 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Botucatu Med Sch, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.identifier.doi10.3390/ijms17081107
dc.identifier.wosWOS:000382337900001
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdCNPq: 478372/2013-2
dc.description.sponsorshipIdCNPq: 305177/2015-0
dc.identifier.fileWOS000382337900001.pdf
unesp.author.orcid0000-0002-9922-2871[1]
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