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dc.contributor.authorDavid, Richard B. [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorDe Luca, Laurival A. [UNESP]
dc.date.accessioned2014-05-20T13:46:08Z
dc.date.available2014-05-20T13:46:08Z
dc.date.issued2008-01-02
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2007.10.009
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1187, p. 137-145, 2008.
dc.identifier.issn0006-8993
dc.identifier.urihttp://hdl.handle.net/11449/16300
dc.description.abstractHypertonic NaCl intake is produced by serotonin receptor antagonism in the lateral parabrachial nucleus (LPBN) of dehydrated rats or in rats pretreated with a mineralocorticoid, for example deoxycorticosterone (DOCA), that receive an intracerebroventricular injection (icv) of angiotensin II (ang II). The objective of the present work was to find out whether these two mechanisms are also involved with isotonic NaCl intake. Serotonin receptor blockade by methysergide in the LPBN (4 mu g/0.2 mu l bilaterally) had no effect on 0.15 M NaCl (methysergide: 19.3 +/- 5.2 ml/60 min; vehicle: 19.3 +/- 4.2 ml/60 min; n=7) or water (methysergide: 3.4 +/- 1.4 ml/ 60 min; vehicle 2.2 +/- 0.6 ml/60 min) intake induced by systemic diuretic furosemide combined with low dose of captopril (Furo/Cap). Methysergide treatment 4 days later in the same animals produced the expected enhancement in the 0.3 M NaCl intake induced by Furo/Cap (methysergide: 16.6 +/- 3.5 ml/60 min; vehicle: 6.6 +/- 1.5 ml/60 min). Similar result was obtained when another group was tested first with 0.3 M NaCl and later with 0.15 M NaCl. Isotonic NaCl intake induced by icv ang II was however enhanced by prior DOCA treatment. A de novo hypertonic NaCl intake was produced in another group by the same combined treatment. The results suggest that a facilitatory mechanism like the mineralocorticoid/ang II synergy may enhance NaCl solution intake at different levels of tonicity, while the action of an inhibitory mechanism, like the LPBN serotonergic system, is restricted to the ingestion at hypertonic levels. (c) 2007 Elsevier B.V. All rights reserved.en
dc.format.extent137-145
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.sourceWeb of Science
dc.subjectdehydrationen
dc.subjectsodium appetiteen
dc.subjectserotoninen
dc.subjectmineral intakeen
dc.subjectpreferenceen
dc.subjectthirsten
dc.titleSerotonergic receptor blockade in the lateral parabrachial nucleus: Different effects on hypertonic and isotonic NaCl intakeen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationSão Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.identifier.doi10.1016/j.brainres.2007.10.009
dc.identifier.wosWOS:000252063900016
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
dc.identifier.lattes1023597870118105
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-5677-1670[1]
unesp.author.orcid0000-0001-8270-2652[3]
unesp.author.orcid0000-0003-1167-4441[2]
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
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