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dc.contributor.authorUscategui, R. A. R. [UNESP]
dc.contributor.authorFeliciano, M. A. R. [UNESP]
dc.contributor.authorTiosso, C. F. [UNESP]
dc.contributor.authorMoro, J. V. [UNESP]
dc.contributor.authorCoutinho, L. N.
dc.contributor.authorBrito, M. B. S. [UNESP]
dc.contributor.authorVicente, W. R. R. [UNESP]
dc.date.accessioned2018-11-26T17:40:24Z
dc.date.available2018-11-26T17:40:24Z
dc.date.issued2017-01-01
dc.identifier.citationPakistan Veterinary Journal. Faisalabad: Univ Agriculture, Fac Veterinary Science, v. 37, n. 3, p. 345-349, 2017.
dc.identifier.issn0253-8318
dc.identifier.urihttp://hdl.handle.net/11449/163178
dc.description.abstractThis study aimed to evaluate pain, anesthetic requirements, and cardiorespiratory variables in bitches subjected to mastectomy that received methadone pre, trans, or postoperatively. Thirty-six bitches undergoing unilateral mastectomy were randomly allocated into 3 groups in a prospective blind clinical trial. Preoperative group (PRE) received 0.5 mg/kg methadone IM 20 minutes prior to anesthesia induction and placebo at the trans and postoperative periods, transoperative group (TRA) received 0.5 mg/kg methadone IM 20 minutes after skin incision and placebo at others periods, and the postoperative group (POS) received 0.5 mg/kg methadone IM once surgery was completed and placebo at other periods. Propofol dose was needed for anesthetic induction (PDI). Heart (HR) and respiratory rate (fR), mean arterial pressure (MAP), blood oxygen saturation (SpO(2)), end tidal CO2 pressure (EtCO2), and isoflurane concentration (EtISO) were evaluated every 10 minutes until the end of the surgical procedure. Pain intensity (Melbourne Pain Scale) and rescue analgesia requirements were evaluated for six hours after surgery. Postoperative pain was lower in PRE and TRA (P=0.036); however, no differences (P=0.410) were observed in postoperative rescue analgesia requirements between the groups, even though only 8% of PRE and TRA patients required it against 25% in POS. MAP and EtCO2 were higher (P<0.001) in PRE and TRA, while EtISO was lower (P<0.001). PRE showed lower PDI (P=0.016) and HR (P=0.003). In conclusion, pre and transoperative methadone administration result in preemptive pain relief, reduce anesthetic requirements, and consequently cause less cardiovascular depression in bitches undergoing mastectomy, although it possibly leads to hypoventilation. (C) 2017 PVJ. All rights reserveden
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent345-349
dc.language.isoeng
dc.publisherUniv Agriculture, Fac Veterinary Science
dc.relation.ispartofPakistan Veterinary Journal
dc.sourceWeb of Science
dc.subjectAnesthetic requirements
dc.subjectAnesthetic sparring
dc.subjectNMDA antagonist
dc.subjectOpioids
dc.subjectPain
dc.subjectPreemptive analgesia
dc.titleComparative Evaluation of Methadone Administration at Different Periods in Bitches Undergoing Mastectomyen
dc.typeArtigo
dcterms.rightsHolderUniv Agriculture, Fac Veterinary Science
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniv Fed Rural Amazonia
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Vet Clin & Surg, Jaboticabal, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Prevent Vet Med & Anim Reprod, Jaboticabal, SP, Brazil
dc.description.affiliationUniv Fed Rural Amazonia, Dept Vet Med, Belem, Para, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Vet Clin & Surg, Jaboticabal, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Prevent Vet Med & Anim Reprod, Jaboticabal, SP, Brazil
dc.identifier.wosWOS:000408791900019
dc.rights.accessRightsAcesso restrito
dc.relation.ispartofsjr0,365
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