Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
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Data
2017-10-01
Autores
Marques, Ana Paula C.
Oliveira, Sandra Maria V. L.
Rezende, Grazielli R.
Melo, Dayane A.
Fernandes-Fitts, Sonia M.
Pontes, Elenir Rose J. C.
Bonecini-Almeida, Maria da Gloria
Camargo, Zoilo P.
Mendes, Rinaldo P. [UNESP]
Paniago, Anamaria M. M.
Título da Revista
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Título de Volume
Editor
Springer
Resumo
We estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant. For the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation. The results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection.
Descrição
Palavras-chave
Paracoccidioidic infection, Booster phenomenon, Intradermal tests, Paracoccidioides brasiliensis, Paracoccidioidomycosis, gp43
Como citar
Mycopathologia. Dordrecht: Springer, v. 182, n. 9-10, p. 809-817, 2017.