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dc.contributor.authorDa Silva, Camila Zambone C. [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorCallera, Joao Carlos [UNESP]
dc.date.accessioned2014-05-20T13:46:15Z
dc.date.available2014-05-20T13:46:15Z
dc.date.issued2011-07-27
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2011.06.004
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1403, p. 28-36, 2011.
dc.identifier.issn0006-8993
dc.identifier.urihttp://hdl.handle.net/11449/16342
dc.description.abstractThe blockade of the lateral parabrachial nucleus (LPBN) with GABA(A) receptor agonist muscimol induces robust hypertonic NaCl and water intake by rats. In the present study we investigated the effects of previous injections of losartan (AT(1) angiotensin receptor antagonist) into the LPBN on 0.3 M NaCl and water intake induced by muscimol injected bilaterally in the same area in fluid replete rats and in rats treated with the diuretic furosemide combined with a low dose of the angiotensin-converting enzyme inhibitor captopril injected subcutaneously. Male Wistar rats with stainless steel cannulas implanted bilaterally into the LPBN were used. Bilateral injections of muscimol (0.5 nmol/0.2 mu l, n=8) into the LPBN in fluid replete rats induced 0.3 M NaCl intake (23.4 +/- 4.1 vs. saline: 0.4 +/- 0.4 ml/3 h) and water intake (9.3 +/- 1.9 vs. saline: 0.7 +/- 0.4 ml/3 h) and pre-treatment of the LPBN with losartan (50 mu g/0.2 mu l) reduced 0.3 M NaCl intake (3.3 +/- 2.5 ml/3 h) and water intake (4.0 +/- 2.9 ml/3 h) induced by muscimol. In rats treated with furosemide + captopril, pretreatment with losartan into the LPBN attenuated the increase of 0.3 M NaCl intake produced by muscimol (12.8 +/- 5.3, vs. saline + muscimol: 36.7 +/- 6.7 ml/3 h) without changing water intake. Therefore, the results suggest that deactivation of LPBN inhibitory mechanisms by muscimol injections into the LPBN is facilitated by endogenous angiotensin II acting on AT(1) receptors in the LPBN, which drives rats to ingest large amounts of hypertonic NaCl. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.format.extent28-36
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.sourceWeb of Science
dc.subjectGABA receptoren
dc.subjectAngiotensin IIen
dc.subjectLosartanen
dc.subjectSodium appetiteen
dc.subjectThirsten
dc.subjectLateral parabrachial nucleusen
dc.titleAT(1) receptor blockade in the lateral parabrachial nucleus reduces the effects of muscimol on sodium intakeen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUniv Estadual Paulista, Dept Basic Sci, Sch Dent, BR-16018805 São Paulo, Brazil
dc.description.affiliationUNESP, Dept Physiol & Pathol, Sch Dent, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Basic Sci, Sch Dent, BR-16018805 São Paulo, Brazil
dc.description.affiliationUnespUNESP, Dept Physiol & Pathol, Sch Dent, Araraquara, SP, Brazil
dc.identifier.doi10.1016/j.brainres.2011.06.004
dc.identifier.wosWOS:000293156800004
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 07/56280-0
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
dc.identifier.fileWOS000293156800004.pdf
dc.identifier.lattes1023597870118105
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[2]
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
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