Clarithromycin as an Adjunct to One-Stage Full-Mouth Ultrasonic Periodontal Debridement in Generalized Aggressive Periodontitis: A Randomized Controlled Clinical Trial
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Data
2017-12-01
Autores
Rebelatto Bechara Andere, Naira Maria [UNESP]
Castro dos Santos, Nidia Cristina [UNESP]
Araujo, Cassia Fernandes [UNESP]
Mathias, Ingrid Fernandes [UNESP]
Taiete, Tiago
Viana Casarin, Renato Correa
Neves Jardini, Maria Aparecida [UNESP]
Shaddox, Luciana Machion
Santamaria, Mauro Pedrine [UNESP]
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Título de Volume
Editor
Amer Acad Periodontology
Resumo
Background: The aim of the present study is to evaluate the periodontal clinical and microbiologic responses and possible adverse effects of clarithromycin (CLM) combined with periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. Methods: Forty patients were selected and randomly assigned into one of two groups: 1) CLM (n = 20): one-stage full-mouth ultrasonic debridement (FMUD) associated with CLM (500 mg, every 12 hours for 3 days); and 2) placebo (n = 20): FMUD associated with placebo pills. Clinical and microbiologic parameters were evaluated at baseline and 3 and 6 months postoperatively. Results: Both treatments presented statistically significant clinical and microbiologic improvements. However, the CLM group presented lower means of probing depth for pockets >7 mm at 6 months (4.0 +/- 1.7 mm) compared with the placebo group (4.7 +/- 1.3 mm) (P = 0.04). In addition, the CLM group also presented greater reduction of Porphyromonas gingivalis (Pg) DNA counts at 6 months (P = 0.0001). Conclusion: Results from this study suggest both treatments are effective; however, adjunct use of CLM to FMUD leads to better reduction of deep pockets and Pg at 6 months compared with FMUD alone.
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Palavras-chave
Aggressive periodontitis, anti-Infective agents, clarithromycin, periodontal debridement, microbiology, ultrasonics
Como citar
Journal Of Periodontology. Chicago: Amer Acad Periodontology, v. 88, n. 12, p. 1244-1252, 2017.