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dc.contributor.authorVesentini, G. [UNESP]
dc.contributor.authorMarini, G. [UNESP]
dc.contributor.authorPiculo, F. [UNESP]
dc.contributor.authorDamasceno, D. C. [UNESP]
dc.contributor.authorMatheus, S. M. M. [UNESP]
dc.contributor.authorFelisbino, S. L. [UNESP]
dc.contributor.authorCalderon, I. M. P. [UNESP]
dc.contributor.authorHijaz, A.
dc.contributor.authorBarbosa, A. M. P. [UNESP]
dc.contributor.authorRudge, M. V. C. [UNESP]
dc.date.accessioned2018-11-26T17:48:26Z
dc.date.available2018-11-26T17:48:26Z
dc.date.issued2018-01-01
dc.identifierhttp://dx.doi.org/10.1590/1414-431X20177035
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 51, n. 4, 10 p., 2018.
dc.identifier.issn0100-879X
dc.identifier.urihttp://hdl.handle.net/11449/163922
dc.description.abstractThe urethral muscle of diabetic pregnant rats is affected by long-term mild diabetes and short-term severe diabetes, which plays a crucial role in the pathogenesis of pelvic floor disorders. We hypothesized that muscles outside the pelvis are subject to similar changes. The current study aimed at analyzing the effects of long-term mild and short-term severe diabetes on the structure and ultrastructure of fiber muscles and collagen in rats' rectus abdominis (RA) muscle. Therefore, the RA muscle of virgin, pregnant, long-term mild diabetic, short-term severe diabetic, long-term mild diabetic pregnant and short-term severe diabetic pregnant 3-month-old Wistar rats were collected. The structure was analyzed by picrosirius red staining, immunohistochemistry for fast and slow muscle fibers and transmission electron microscopy. We investigated two levels of STZ-induced diabetes: long-term mild diabetes (blood glucose level: 120-200 mg/dL) and short-term severe diabetes (blood glucose level 4300 mg/dL). Long-term mild diabetic pregnant and short-term severe diabetic pregnant rats had decreased fast fibers and increased slow fibers, disrupted areas of sarcomere, intermyofibrillar mitochondria and myelin figures in the RA muscle. Both groups enabled us to analyze the specific influence of pregnancy, separately from diabetes. The current study demonstrated that diabetes and pregnancy induced intramuscular transformation and reorganization of RA muscle with a switch of fiber type adjusting their architecture according to intensity and duration of hyperglycemic insult within pregnancy.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent10
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.sourceWeb of Science
dc.subjectDiabetes
dc.subjectPregnancy
dc.subjectCollagen
dc.subjectSkeletal muscle
dc.subjectRats
dc.titleMorphological changes in rat rectus abdominis muscle induced by diabetes and pregnancyen
dc.typeArtigo
dcterms.rightsHolderAssoc Bras Divulg Cientifica
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniv Sagrado Coracao
dc.contributor.institutionUniv Hosp Case Med Ctr
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Dept Ginecol & Obstet, Botucatu, SP, Brazil
dc.description.affiliationUniv Sagrado Coracao, Dept Ciencias Saude, Sagrado, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Anat, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Morfol, Botucatu, SP, Brazil
dc.description.affiliationUniv Hosp Case Med Ctr, Urol Inst, Dept Urol, Cleveland, OH USA
dc.description.affiliationUniv Estadual Paulista, Dept Fisioterapia & Terapia Ocupac, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, Dept Ginecol & Obstet, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Anat, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Morfol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fisioterapia & Terapia Ocupac, Botucatu, SP, Brazil
dc.identifier.doi10.1590/1414-431X20177035
dc.identifier.wosWOS:000426394200001
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: FAPESP 2012/25053-7
dc.description.sponsorshipIdFAPESP: 2014/14144-7
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