Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27
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Data
2018-02-01
Autores
Silva, Gabriel
Lima, Felipe Teixeira
Seba, Viviane
Mendes Lourenco, Ana Laura
Lucas, Thaise Graminha
Andrade, Bianca Vieira de
Torrezan, Guilherme Silva [UNESP]
Polaquini, Carlos Roberto [UNESP]
Garcia, Marcelo Engracia
Couto, Lucelio Bernardes
Título da Revista
ISSN da Revista
Título de Volume
Editor
Mdpi
Resumo
Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.
Descrição
Palavras-chave
gastric cancer, curcumin, matrix metalloproteinase 2, migration, invasion, apoptosis
Como citar
Molecules. Basel: Mdpi, v. 23, n. 2, 10 p., 2018.