Expression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients: a pilot study
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2018-04-01
Autores
Galvis, Marisol Miranda
Jardim, Juscelino Freitas
Kaminagakura, Estela [UNESP]
Santos-Silva, Alan Roger
Fonseca, Felipe Paiva
Almeida, Oslei Paes
Lopes, Marcio Ajudarte
Pinto, Clovis Lopes
Kowalski, Luiz Paulo
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Elsevier B.V.
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Objective. Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients. Methods. A tissue microarray construction based on 34 OSCC samples from young patients (<40 years old) was subjected to immunohistochemical reactions for Ki67, cyclin D1, C-ErbB2, p21, Myc, epidermal growth factor receptor, p53, and p16 antibodies. Results. The clinicopathologic features and the immunoexpression of all tested proteins were similar in both groups. Patients with HPV-related OSSC tended to have better cancer-specific survival (CSS; 39% vs 60% 5-y CSS), and overall survival (OS; 29.2% vs 60% 5-year OS). However, this difference was not statistically significant. Conclusion. No significant difference exists in the expression of cell cycle proteins studied between HR-HPV DNA-positive and HR-HPV DNA-negative OSCC affecting young patients.
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Oral Surgery Oral Medicine Oral Pathology Oral Radiology. New York: Elsevier Science Inc, v. 125, n. 4, p. 317-325, 2018.