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dc.contributor.authorAraujo, M. V. T.
dc.contributor.authorSpadella, M. A.
dc.contributor.authorChies, A. B.
dc.contributor.authorArruda, G.
dc.contributor.authorSantos, T. de M. [UNESP]
dc.contributor.authorCavariani, M. M. [UNESP]
dc.contributor.authorDomeniconi, R. F. [UNESP]
dc.date.accessioned2018-11-26T17:54:41Z
dc.date.available2018-11-26T17:54:41Z
dc.date.issued2018-08-01
dc.identifierhttp://dx.doi.org/10.1016/j.tice.2018.06.006
dc.identifier.citationTissue & Cell. Edinburgh: Churchill Livingstone, v. 53, p. 104-110, 2018.
dc.identifier.issn0040-8166
dc.identifier.urihttp://hdl.handle.net/11449/164471
dc.description.abstractHead and neck cancers are common in several regions of the world and the treatment usually includes radiotherapy. This treatment can generate adverse effects to the salivary flow, with a relationship between the dose and the damage caused. Salivary gland cells are highly permeable to water and therefore, they express aquaporins (AQPs). This study analyzed changes in the expression and location of these proteins and identified morphological changes induced by low radiation in rat submandibular gland. Female rats were divided into control and irradiated groups. Immunohistochemistry analysis allowed confirming the presence of AQP1 in the blood vessel endothelium. Intense and steady labelling granules were also observed in the cytoplasm of submandibular gland ductal cells. In addition, there was AQP5 positive labelling in ductal cells delimiting the lumen of intercalated duct, in the cytoplasm and membrane of acinar cells. Finally, the decrease of AQP labelling in irradiated animal glands validated their radiosensitivity. Thus, the decrease in AQP1 protein levels in the endothelium and AQP5 in gland ductal cells of irradiated animals may have hindered the removal of water from the lumen of ductal cells, inducing a delay in water absorption and triggering a slight lumen increase.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent104-110
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofTissue & Cell
dc.sourceWeb of Science
dc.subjectSalivary glands
dc.subjectIrradiation
dc.subjectWater channels
dc.titleEffect of low radiation dose on the expression and location of aquaporins in rat submandibular glanden
dc.typeArtigo
dcterms.rightsHolderChurchill Livingstone
dc.contributor.institutionFac Med Marilia FAMEMA
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationFac Med Marilia FAMEMA, Marilia, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, Dept Anat, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, Dept Anat, Botucatu, SP, Brazil
dc.identifier.doi10.1016/j.tice.2018.06.006
dc.identifier.wosWOS:000440173900014
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2013/07203-4
dc.identifier.fileWOS000440173900014.pdf
dc.identifier.lattes5481756528299469
dc.identifier.orcid0000-0003-2938-010X
unesp.author.lattes5481756528299469[7]
unesp.author.orcid0000-0003-2938-010X[7]
dc.relation.ispartofsjr0,410
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