Expression of HLA-E molecules in the placental tissue of women infected with HIV-1 and uninfected women
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Data
2017-01-01
Autores
Martinez, Juliana
Santiago, Mariana Rodrigues
Martelli-Palomino, Gustavo
Souza, Diego Agra de
Alves Silva, Tarsia Giabardo [UNESP]
Barros Silva, Gyl Eanes
Chahud, Fernando
Donadi, Eduardo Antonio
Morais Fernandes, Ana Paula
Título da Revista
ISSN da Revista
Título de Volume
Editor
W B Saunders Co Ltd
Resumo
Introduction: Expression of HLA-E molecule in the placental extravillous trophoblast is associated with immune system cell inhibition, resulting in immune tolerance to fetus during pregnancy. HIV-1 can infect trophoblast cells and modify the expression of HLA-E, which may inhibit the cytotoxic activity of the immune system. Aim: The aim of this study was to evaluate HLA-E expression in third trimester placental tissue of women infected with HIV-1 and uninfected women. Methods: We performed an immunohistochemistry assay to evaluate HLA-E staining in the placental tissue of 99 HIV-1 infected and 85 uninfected women. A pathologist analyzed and classified the HLA-E expression in the placental cells. Results: Irrespective of the HIV status, HLA-E staining was observed in the extravillous trophoblast cells, endothelial cells and Hofbauer cells, but not in the syncytiotrophoblast. HLA-E staining showed no significant difference between the placental tissue of women infected with HIV-1 and uninfected women (P = 0.76). Considering HIV-1 infected women, HLA-E staining was not influenced by HIV-1 viral load (P = 0.48), CD4(+) T-cell count (P = 0.10) and antiretroviral therapy used during pregnancy (P = 0.54). Discussion: Despite the presence of HIV-1 infection, the expression of HLA-E molecules in the placental tissue was not modified when the infection was under antiretroviral therapy control. (C) 2016 Published by Elsevier Ltd.
Descrição
Palavras-chave
HLA-E, Expression, Placenta, HIV-1
Como citar
Placenta. London: W B Saunders Co Ltd, v. 49, p. 33-36, 2017.