Evaluation of the Osteoinductive Effect of PDGF-BB Associated With Different Carriers in Bone Regeneration in Bone Surgical Defects in Rats
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Data
2017-08-01
Autores
Silva de Oliveira, Julio Cesar
Okamoto, Roberta
Sonoda, Celso Koogi
Poi, Wilson Roberto
Garcia Junior, Idelmo Rangel
Luvizuto, Eloa Rodrigues
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Editor
Lippincott Williams & Wilkins
Resumo
Purpose: Extensive bone defects in maxillofacial region can be corrected with autograft. However the disadvantages of this type of therapy lead to the search for new bone substitutes. Thus, we evaluated the biological behavior and osteoinductive platelet-derived growth factor type BB (PDGF-BB) associated with different carriers, by histological analysis and immunohistochemical histometric critical defects performed in rat calvaria. Materials and Methods: Critical defects were created with 5-mm diameter calvaria of rats. Each defect was randomly divided into 8 experimental groups, evaluated at 15 and 30 postoperative days for histomorphometry and immunohistochemistry. Results: The results showed new bone formation in all groups, independent of postoperative time. At 30 days, the beta-tricalcium phosphate matrix (TCP) group just did not differ from bone matrix mineralized bovine (BIO) group in the new bone formation (P = 0.1403). In none of the groups' analyzed biomaterials, growth factor stimulated increase in bone formation (P > 0.05). Conclusion: With the methodology used, the growth factor associated with the tested biomaterials did not induce new bone formation.
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Palavras-chave
bone regeneration, platelet-derived growth factor, surgical defects, osteoinductive effects, rats
Como citar
Implant Dentistry. Philadelphia: Lippincott Williams & Wilkins, v. 26, n. 4, p. 559-566, 2017.