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dc.contributor.authorMattos, Marlon Fraga
dc.contributor.authorBiselli-Chicote, Patricia Matos
dc.contributor.authorBiselli, Joice Matos [UNESP]
dc.contributor.authorSilva Assembleia, Thiago Luis da
dc.contributor.authorGoloni-Bertollo, Eny Maria
dc.contributor.authorPavarino, Erika Cristina
dc.date.accessioned2018-11-26T22:40:49Z
dc.date.available2018-11-26T22:40:49Z
dc.date.issued2018-01-01
dc.identifierhttp://dx.doi.org/10.1155/2018/6539548
dc.identifier.citationMediators Of Inflammation. London: Hindawi Ltd, 9 p., 2018.
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/11449/164826
dc.description.abstractImmunological impairment is a condition that is often observed in individuals with Down syndrome (DS). The immune response is modulated by pro- and anti-inflammatory cytokines whose expressions could be influenced by genetic polymorphisms. The present study was aimed at evaluating the frequencies of -174G>C, -572G>C, and -597G>A polymorphisms in the interleukin 6 (IL-6) gene and -592C>A, -1082A>G, and -819C>T polymorphisms in the IL-10 gene and the IL-6 and IL-10 serum levels in healthy individuals with and without DS. The authors also aimed to investigate the impact of the genotypes on the interleukin concentrations. The genetic polymorphisms were investigated in 200 DS individuals and 200 controls without DS. The serum measurement of IL-6 and IL-10 was performed in a subgroup (54 cases and 54 controls) by enzyme-linked immunosorbent assay (ELISA). The frequencies of the polymorphisms and haplotypes evaluated were not different between individuals with and without DS. IL-10 concentration was higher in DS children but was not influenced by IL-10 gene polymorphisms. IL-6 genotypes had no influence on IL-6 serum levels. The IL-10 serum levels are increased in DS individuals, but IL-10 polymorphisms are not the main factors that influence the IL-10 expression in DS.en
dc.description.sponsorshipFaculdade de Medicina de Sao Jose do Rio Preto (FAMERP)
dc.description.sponsorshipHospital de Base, Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundacao de Apoio a Pesquisa e Extensao de Sao Jose do Rio Preto (FAPERP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent9
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofMediators Of Inflammation
dc.sourceWeb of Science
dc.titleInterleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndromeen
dc.typeArtigo
dcterms.rightsHolderHindawi Ltd
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationFac Med Sao Jose do Rio Preto, Unidade Pesquisa Genet & Biol Mol, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP, Brazil
dc.identifier.doi10.1155/2018/6539548
dc.identifier.wosWOS:000442883500001
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdCNPq: 308551/2014-1
dc.description.sponsorshipIdFAPESP: 2014/26218-5
dc.description.sponsorshipIdFundacao de Apoio a Pesquisa e Extensao de Sao Jose do Rio Preto (FAPERP): 21/2015
dc.identifier.fileWOS000442883500001.pdf
dc.relation.ispartofsjr1,370
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