Now showing items 1-10 of 30
Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model
(Brain Research, 2015) [Artigo]
Sildenafil (Viagra®) has recently been found to have a neuroprotective effect, which occurs through the inhibition of inflammation and demyelination in the cerebellum. However, the mechanism of action of sildenafil remains ...
Biology of bone tissue: structure, function, and factors that influence bone cells
(BioMed Research International, 2015) [Artigo]
Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators ...
Cimetidine-induced Leydig cell apoptosis and reduced EG-VEGF (PK-1) immunoexpression in rats: evidence for the testicular vasculature atrophy
(Reproductive Toxicology (elmsford, N.y.), 2015) [Artigo]
The antiulcer drug cimetidine has shown to cause changes in the testicular microvasculature of adult rats. Since Leydig cells (LCs) produce the pro-angiogenic factor, EG-VEGF (endocrine gland-derived vascular endothelial ...
Immunolocalization of osteocalcin in matrix-vesicles in the early developing alveolar process of rat molars.
(Molecular Biology Of The Cell, 2015-01-01) [Resumo]
The antineoplastic busulphan impairs peritubular and Leydig cells, and vitamin B-12 stimulates spermatogonia proliferation and prevents busulphan-induced germ cell death
(Biomedicine & Pharmacotherapy, 2017-11-01) [Artigo]
Busulphan (Bu), an alkylating agent used for bone marrow and spermatogonial stem cell transplantation (SSCT), impairs Sertoli (SC) cells, which are necessary for the spermatogonial stem cell (SSC) homing during transplantation. ...
Cimetidine Reduces Alveolar Bone Loss in Induced Periodontitis in Rat Molars
(Journal Of Periodontology, 2014-08-01) [Artigo]
Background: There is evidence that histamine released during inflammation plays a role in bone metabolism via the H-2 receptor, stimulating bone resorption. The purpose of this study is to evaluate whether cimetidine, a ...
Histological and histomorphometrical evaluation of furcation perforations filled with MTA, CPM and ZOE
(International Endodontic Journal, 2011-02-01) [Artigo]
P>AimTo evaluate the biological response of the periodontium adjacent to furcation perforations in rat molars filled with Endo-CPM-Sealer (CPM), MTA-Angelus (MTA) or zinc oxide-eugenol cement (ZOE).MethodologyThe pulp ...
Biocompatibility of an experimental MTA sealer implanted in the rat subcutaneous: Quantitative and immunohistochemical evaluation
(Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2012-10-01) [Artigo]
The tissue reaction promoted by an experimental mineral trioxide aggregate sealer (MTAS) in the rat subcutaneous was evaluated by morphological and morphometric analyses. In the animals from each group (n = 20), polyethylene ...
Seminiferous epithelium damage after short period of busulphan treatment in adult rats and vitamin B12 efficacy in the recovery of spermatogonial germ cells
(International Journal of Experimental Pathology, 2016-08-01) [Artigo]
Several different strategies have been adopted in attempt to recover from chemotherapy-damaged spermatogenesis that is often seen in oncologic patients. In this study, we have evaluated the impact of short period of exposure ...
Investigation of in vitro and in vivo potential of Phoneutria nigriventer spider venom against human glioma
(Glia, 2017-06-01) [Resumo]